公开(公告)号：EP1363648A1

公开(公告)日：2003-11-26

申请号：EP01274005.6

申请日：2001-12-20

申请人： Korea Institute of Bioscience and Biotechnology

发明人： LEE, Hyeong Kyu ,  OH, Sei Ryang,Apt. 1130 ,  AHN, Kyung Seop ,  CHOI, Soon Ja ,  KIM, Jung Hee ,  OH, Goo Taeg ,  HONG, Jung Joo ,  PARK, Seong Kyu ,  NAMKUNG, Woo,933-304 GajokSaenghwaldong

IPC分类号： A61K35/78

CPC分类号： A61K36/532 ,  A23L33/105 ,  A23L33/11

摘要： The present invention relates to a composition comprising Agastache rugosa and tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, to an extract of Agastache rugosa and tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement system as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.

公开(公告)号：EP1363648B1

公开(公告)日：2006-11-15

申请号：EP01274005.6

申请日：2001-12-20

申请人： Korea Institute of Bioscience and Biotechnology

发明人： LEE, Hyeong Kyu ,  OH, Sei Ryang, Apt. 1130 ,  AHN, Kyung Seop ,  CHOI, Soon Ja ,  KIM, Jung Hee ,  OH, Goo Taeg ,  HONG, Jung Joo ,  PARK, Seong Kyu ,  NAMKUNG, Woo, 933-304 GajokSaenghwaldong

IPC分类号： A61K31/704 ,  A61P3/10 ,  A61P29/00 ,  A61K36/532

CPC分类号： A61K36/532 ,  A23L33/105 ,  A23L33/11

摘要： The present invention relates to a composition comprising Agastache rugosa and tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, to an extract of Agastache rugosa and tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement system as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.