专利检索 ap:("Korea Institute of Ocean Science AND Technology" OR "Cha, Kiweon") AND inv:"YIM, Hyung-Soon" 第 1 页

1.

发明公开
FGF2 POLYPEPTIDE WITH IMPROVED TEMPERATURE STABILITY AND PROTEASE RESISTANCE AND USE THEREOF 审中-公开

公开(公告)号：EP4067374A1

公开(公告)日：2022-10-05

申请号：EP20894591.5

申请日：2020-11-16

申请人： Korea Institute of Ocean Science and Technology , Cha, Kiweon

发明人： LEE, Jung-Hyun , YIM, Hyung-Soon , AN, Young Jun , LEE, Kyeong Won , JEONG, Ye Eun , LEE, Won Kyu , WOO, Jurang , CHA, Kiweon

IPC分类号： C07K14/50 , C12N5/0735 , C12N5/074 , A61K8/64 , A61P17/00 , A61Q19/00 , A61K38/00

摘要： Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (W) at position 96 in SEQ ID NO: 1.