公开(公告)号：EP3901139A1

公开(公告)日：2021-10-27

申请号：EP18944116.5

申请日：2018-12-26

申请人： Korea Institute of Science and Technology

发明人： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  SEONG, Jihye ,  LEE, Jae Wook ,  SONG, Ji Yeon ,  SHIN, Seulgi ,  JEONG, Hyean Jeong ,  SON, Woo Seung ,  LEE, Haeun ,  LIM, Da Mi ,  KIM, Seok Kyu ,  AHN, Jee Yun ,  KIM, Chae Won ,  LONDHE, Ashwini Machhindra ,  GOTINA, Lizaveta ,  KIM, Hyojin ,  LEE, Hye Yeon ,  KIM, Nam Gyung ,  CHA, Eunji ,  KIM, Kunhee ,  LIM, Ji Woong

IPC分类号： C07D213/04 ,  A61K31/505 ,  A61K31/425 ,  C07D277/20 ,  C07D241/10 ,  C07D249/08 ,  C07D217/04 ,  C07D231/56 ,  C07D209/04 ,  C07D487/04

摘要： The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

公开(公告)号：EP3560927A1

公开(公告)日：2019-10-30

申请号：EP17811428.6

申请日：2017-11-06

申请人： Korea Institute of Science and Technology

发明人： CHOO, Hyunah ,  KIM, Youngjae ,  SEONG, Jihye ,  NAM, Ghil Soo ,  CHO, Yong Seo

IPC分类号： C07D487/04 ,  A61K31/55

摘要： Azepine derivatives acting on 5-HT 7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT 7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT 7 receptors antagonistic activity is required.