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    Composition comprising an HMG-CoA inhibitor and a nicotinic acid compound for treating hyperlipidemia
    1.
    发明公开
    Composition comprising an HMG-CoA inhibitor and a nicotinic acid compound for treating hyperlipidemia 失效
    包括用于治疗高脂血症的HMG-CoA还原酶抑制剂和烟酸化合物的组合物

    公开(公告)号：EP1792616A1

    公开(公告)日：2007-06-06

    申请号：EP07003276.8

    申请日：1998-07-31

    申请人： Kos Life Sciences, Inc.

    发明人： Bova, David J. ,  Dunne, Josephine

    IPC分类号： A61K31/455 ,  A61K31/785 ,  A61K9/20

    CPC分类号： A61K45/06 ,  A61K9/2054 ,  A61K9/209 ,  A61K31/455 ,  A61K31/44 ,  A61K31/40 ,  A61K31/365 ,  A61K31/22 ,  A61K2300/00

    摘要： An extended or sustained release composition for oral administration to alter serum lipid levels in an individual without causing drug-induced hepatotoxicity, rhabdomyolysis or myopathy, the composition comprising from 250 mg to 3000 mg of nicotinic acid or a compound metabolised to nicotinic acid by the body selected from the group consisting of nicotinyl alcohol tartrate, d-glucitol hexanicotinate, aluminium nicotinate, niceritrol, d,l-alpha-tocopheryl nicotinate, 6-OH-nicotinic acid, nicotinaria acid, nicotinamide, nicotinamide-N-Oxide, 6-OH-nicotinamide, NAD, N-methyl-2-pyrridine-8-carboxamide, N-methyl-nicotinamide, N-ribosyl-2-pyridone-5-carboxide, N-methyl-4-pyridone-5-carboxamide, bradilian, sorbinicate, hexanicite, ronitol, and methyl, ethyl, propyl or butyl alcohol esters of nicotinic acid or combinations thereof, coated with an immediate release coating of from 0.1 mg to 80 mg of an HMG-CoA reductase inhibitor.

    摘要翻译： 用于口服给药的延长或持续释放组合物，以改变在个体的血清脂质水平，而不会引起药物诱导的肝毒性，横纹肌溶解或肌病，所述组合物从250毫克包括至3000mg烟酸的或由体内代谢烟碱酸的化合物 选自烟酰醇酒石酸盐，D-葡萄糖醇六烟，烟酸铝，戊四烟酯，D，L-α-生育酚烟酸酯，6-OH-烟酸，nicotinaria酸，烟酰胺，烟酰胺-N-氧化物，6-OH的选择 - 烟酰胺，NAD，N-甲基-2-吡啶-8-甲酰胺，N-甲基烟酰胺，N-核糖基-2-吡啶酮-5- carboxides，N-甲基-4-吡啶-5-甲酰胺，bradilian，sorbinicate ，烟酸或其组合的hexanicite，ronitol，和甲基，乙基，丙基或丁基醇酯，在从0.1毫克至80毫克的HMG-CoA还原酶抑制剂的立即释放包衣涂布。