公开(公告)号：EP2121957A1

公开(公告)日：2009-11-25

申请号：EP08724771.4

申请日：2008-01-23

申请人： Kosan Biosciences, Inc.

发明人： ASHLEY, Gary ,  MENZELLA, Hugo, G. ,  WEE, Janice, Lau ,  CARNEY, John, R.

IPC分类号： C12P19/62 ,  A01N43/04 ,  A61K31/70

CPC分类号： C12P17/10 ,  C07D225/06

摘要： Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.