公开(公告)号：EP1282626A2

公开(公告)日：2003-02-12

申请号：EP01935329.1

申请日：2001-05-10

申请人： Kosan Biosciences, Inc.

发明人： Chu, Daniel ,  Fardis, Maria ,  Khosla, Chaitan ,  Reeves, Christopher ,  Santi, Daniel ,  Schirmer, Andreas

IPC分类号： C07D498/18 ,  C12P17/18

CPC分类号： C07D498/18

摘要： The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods for their use. The compounds of the present invention are cyclic polyketides (also referred to as a 'macrolides' or 'macrolactones') that include Formula (I) as part of their structure and bind to a FK binding protein wherein R?4 and R5¿ are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R?4 and R5¿ is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.