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    ARCTIGENIN-CONTAINING BARDANAE FRUCTUS EXTRACT AND METHOD FOR PRODUCING SAME
    1.
    发明公开
    ARCTIGENIN-CONTAINING BARDANAE FRUCTUS EXTRACT AND METHOD FOR PRODUCING SAME 审中-公开
    维多利亚州泽西尔赫斯特朗

    公开(公告)号：EP2623107A1

    公开(公告)日：2013-08-07

    申请号：EP11829102.0

    申请日：2011-09-27

    申请人： Kracie Pharma, Ltd. ,  National Cancer Center ,  National University Corporation University Of Toyama

    发明人： OKUBO, Toshiki ,  YOMODA, Satoshi ,  FUSE, Takafumi ,  KAWASHIMA, Takanori ,  ESUMI, Hiroyasu ,  MIYOSHI, Chika ,  KADOTA, Shigetoshi

    IPC分类号： A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  A61K36/00 ,  A61P35/00 ,  C07D307/33

    CPC分类号： A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  A61K2236/19 ,  C07D307/33

    摘要： PROBLEM TO BE SOLVED
    The present invention is intended to provide a burdock fruit extract containing arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract containing arctigenin and arctiin at a weight ratio of approximately 1:1.
    SOLUTION
    A method for producing a burdock fruit extract containing arctigenin and arctiin at a weight ratio of arctigenin/arctiin = 0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20°C to 50°C. Also provided is the method further including a step of extracting an extract containing arctigenin and arctiin by adding an organic solvent and heating to reflux.

    摘要翻译： 待解决的问题本发明旨在提供一种含有一定比例的抗坏血酸和铁蛋白的牛蒡果实提取物及其制造方法。 更具体地说，本发明旨在提供一种以大约1:1的重量比生产含有抗坏血酸和铁蛋白的牛蒡果实提取物的方法。 解决方案提供一种含有抗坏血酸素/ arctinin = 0.7〜1.3的重量比的红曲霉素和arctiin的牛蒡果实提取物的方法，包括以下步骤：将牛蒡水果切割成牛蒡果实固有的arctiin， 牛蒡果实固有的β-葡糖苷酶的酶转化，其中酶促转化包括在20℃至50℃的温度下进行反应。 该方法还包括通过加入有机溶剂并加热回流来提取含有抗坏血酸和铁蛋白的提取物的步骤。