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公开(公告)号：EP2014670A3
公开(公告)日：2010-05-19
申请号：EP08104378.8
申请日：2008-06-11
发明人： West, Leslie George , Pomerleau, Theresa , Matusheski, Nathan V. , Ludwig, Cathy Jean , Hestekin, Jamie , Crowley, Colin , Kim, Nam-Cheol
IPC分类号： C07H15/14 , C07H1/08 , A61K31/7028 , A61P35/00
摘要： The present invention relates to a process for producing glucosinolates, particularly glucoraphanin, from cruciferous plants. More particularly, a method is provided for producing glucosinolates from agricultural by-products and waste. The general method comprises providing a mixture of glucosinolate-containing plant material and liquid, heating the mixture to inactivate enzymes in the plant material, contacting the heat inactivated mixture with an anion exchange membrane whereby at least a portion of the glucosinolates are extracted from the liquid and absorbed onto the anion exchange membrane, and releasing the glucosinolates from the anion exchange membrane. Preferably, the extraction and release steps are repeated at least once. The glucosinolates produced by the method of the invention may be incorporated into a variety of food products, pharmaceuticals, and health supplements.
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公开(公告)号：EP2014670B1
公开(公告)日：2012-11-14
申请号：EP08104378.8
申请日：2008-06-11
发明人： West, Leslie George , Pomerleau, Theresa , Matusheski, Nathan V. , Ludwig, Cathy Jean , Hestekin, Jamie , Crowley, Colin , Kim, Nam-Cheol
IPC分类号： C07H15/14 , C07H1/08 , A61K31/7028 , A61P35/00
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公开(公告)号：EP2065034A3
公开(公告)日：2011-08-31
申请号：EP08104379.6
申请日：2008-06-11
发明人： West, Leslie George , Windsor, Nicole Lee , Gaonkar, Anilkumar Ganapati , Matusheski, Nathan V. , Kim, Nam-Cheol , Ludwig, Cathy Jean , Lawrence, Leslie Lewis
IPC分类号： A61K9/16 , A61K9/50 , A61K31/375 , A61K38/47 , A61K31/7028
CPC分类号： A61K9/1652 , A61K9/5063 , A61K31/375 , A61K31/7028 , A61K38/47 , A61K2300/00
摘要： The present invention relates to a particulate composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. The present invention further provides a method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. In another aspect, uncoated glucosinolate and beta-thioglucosidase particles may be provided in an enteric-coated capsule. Preferably, the glucosinolate is glucoraphanin and the beta-thioglucosidase is myrosinase. The enteric coating targets the compound for release in the small intestine where beta-thiaglucosidase enzyme converts glucosinolate to chemoprotectant isothiocyanate.
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