公开(公告)号：EP1319662A1

公开(公告)日：2003-06-18

申请号：EP01965636.2

申请日：2001-09-14

申请人： Kuraray Co., Ltd. ,  SAGAMI CHEMICAL RESEARCH CENTER

发明人： KUWAYAMA, Tomoya, c/o KURARAY CO., LTD ,  UJITA, Katsuji, c/o KURARAY CO., LTD ,  SHIMIZU, Kazuya, c/o KURARAY CO., LTD ,  TERASHIMA, Shiro

IPC分类号： C07D493/08

CPC分类号： C07D493/08

摘要： The present invention provides a method of industrially advantageously producing 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid derivatives under mild conditions in a high yield. The present invention relates to a production method of a 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid derivative of the formula (III) or the formula (IV), which comprises reacting an α,β-unsaturated carboxylic acid of the formula (I) with a furan derivative of the formula (II) in the presence of a Lewis acid:
wherein each symbol is as defined in the specification.

摘要翻译： 本发明提供了一种工业上有利地以高产率在温和条件下生产7-氧杂双环-2,2-庚-5-烯-2-羧酸衍生物的方法。 本发明涉及式（III）或式（IV）的7-氧杂双环-2,2-庚-5-烯-2-羧酸衍生物的制备方法，其包括使α，β-不饱和羧酸 式（I）与式（II）的呋喃衍生物在路易斯酸：CHEM的存在下反应，其中每个符号如说明书中所定义.a