公开(公告)号：EP3111966A1

公开(公告)日：2017-01-04

申请号：EP16175576.4

申请日：2006-01-06

申请人： Kuros Biosurgery AG

发明人： Schense, Jason ,  Watson, John ,  Arrighi, Isabelle

IPC分类号： A61L27/22 ,  A61L27/12

CPC分类号： A61K38/29 ,  A61L27/12 ,  A61L27/225 ,  A61L27/227 ,  A61L27/46 ,  A61L2430/02 ,  C07K14/635 ,  C07K2319/00

摘要： Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible and biodegradable and can be formed in vitro or in vivo, at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated, using techniques that provide control over how and when and to what degree the PTH is released using the matrix as a controlled release vehicle to heal bone fractures.

摘要翻译： 包含可释放地结合在其中的可选地含有颗粒材料的PTH的补充基质在本文中描述。 PTH通过共价键连接到基质中或通过与基质和/或颗粒的非共价相互作用而掺入。 与自体移植相比，这些补充的基质减少愈合时间和/或触发骨折的愈合，否则将不会愈合。 该基质是生物相容性的并且是可生物降解的并且可以在植入时在体外或体内形成。 PTH可能是融合肽的一部分。 PTH可以并入到具有完全保留其生物活性的基质中。 PTH可以可释放地并入，使用技术来控制使用基质作为受控释放载体来治疗骨折的PTH释放的如何和何时以及在什么程度上。

公开(公告)号：EP2316497A3

公开(公告)日：2014-05-07

申请号：EP10181752.6

申请日：2006-01-06

申请人： Kuros Biosurgery AG

发明人： Schense, Jason ,  Watson, John ,  Arrighi, Isabelle

IPC分类号： A61L27/22 ,  A61L27/12 ,  A61L27/46 ,  A61K38/29 ,  C07K14/635

CPC分类号： A61K38/29 ,  A61L27/12 ,  A61L27/225 ,  A61L27/227 ,  A61L27/46 ,  A61L2430/02 ,  C07K14/635 ,  C07K2319/00

摘要： Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible and biodegradable and can be formed in vitro or in vivo , at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated, using techniques that provide control over how and when and to what degree the PTH is released using the matrix as a controlled release vehicle to heal bone fractures.

公开(公告)号：EP2316497A2

公开(公告)日：2011-05-04

申请号：EP10181752.6

申请日：2006-01-06

申请人： Kuros Biosurgery AG

发明人： Schense, Jason ,  Watson, John ,  Arrighi, Isabelle

IPC分类号： A61L27/22 ,  A61L27/12

CPC分类号： A61K38/29 ,  A61L27/12 ,  A61L27/225 ,  A61L27/227 ,  A61L27/46 ,  A61L2430/02 ,  C07K14/635 ,  C07K2319/00

摘要： Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible and biodegradable and can be formed in vitro or in vivo , at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated, using techniques that provide control over how and when and to what degree the PTH is released using the matrix as a controlled release vehicle to heal bone fractures.

摘要翻译： 包含可释放地结合在其中的可选地含有颗粒材料的PTH的补充基质在本文中描述。 PTH通过共价键连接到基质中或通过与基质和/或颗粒的非共价相互作用而掺入。 与自体移植相比，这些补充的基质减少愈合时间和/或触发骨折的愈合，否则将不会愈合。 该基质是生物相容性的并且是可生物降解的并且可以在植入时在体外或体内形成。 PTH可能是融合肽的一部分。 PTH可以并入到具有完全保留其生物活性的基质中。 PTH可以可释放地并入，使用技术来控制使用基质作为受控释放载体来治疗骨折的PTH释放的如何和何时以及在什么程度上。