公开(公告)号：EP3978032A1

公开(公告)日：2022-04-06

申请号：EP20813023.7

申请日：2020-05-27

申请人： Kyoto University ,  National Cerebral and Cardiovascular Center ,  JSR Corporation

发明人： KONDO, Teruyuki ,  KIMURA, Yu ,  SON, Aoi ,  MATSUDA, Tetsuya ,  IMAI, Hirohiko ,  KOSEKI, Hirokazu ,  AOKI, Tomohiro ,  TAKASE, Katsuyuki ,  MIYAJI, Masaaki ,  TAMORI, Koji ,  MASUDA, Takeaki ,  KAI, Hirokazu

IPC分类号： A61K49/08 ,  A61B5/055

摘要： Composite particles, each of which is obtained by forming, on the surface of a gadolinium oxide-containing particle, a cover film that contains a polymer obtained by polymerizing a monomer component containing a monomer having an ethylenically unsaturated bond; a macrophage imaging agent which contains the composite particles; and a method for producing composite particles, wherein a monomer component containing a monomer having an ethylenically unsaturated bond and gadolinium oxide-containing particles are mixed with each other, and after emulsifying the thus-obtained monomer component-containing mixture in water in the presence of a surfactant and a polymerization initiator in water, the monomer component is polymerized, thereby forming cover films on the surfaces of the gadolinium oxide-containing particles.