公开(公告)号：EP2520648A1

公开(公告)日：2012-11-07

申请号：EP10841044.0

申请日：2010-12-28

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： KANEKO, Etsuji ,  SASAKI, Yuka ,  MORI, Katsuhiro ,  KANDA, Yutaka ,  SATOH, Mitsuo

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P13/12 ,  A61P37/02 ,  C07K16/42 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/53

CPC分类号： C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.