公开(公告)号：EP0882717B1

公开(公告)日：2010-09-08

申请号：EP97943133.5

申请日：1997-10-01

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： MATSUNO, Kenji ,  ICHIMURA, Michio ,  NOMOTO, Yuji ,  FUJIWARA, Shigeki ,  IDE, Shinichi ,  TSUKUDA, Eiji ,  IRIE, Junko ,  ODA, Shoji

IPC分类号： C07D215/46 ,  C07D217/22 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  A61K31/495 ,  A61K31/50 ,  A61P9/10

CPC分类号： C07D401/12 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  C07D215/46 ,  C07D217/22 ,  C07D237/34 ,  C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

摘要： Nitrogenous heterocyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which hinder the phosphorylation of PDGF acceptors and the abnormal proliferation or migration of cells and so are effective in preventing or treating cell proliferative diseases such as arterial sclerosis, vascular reocclusion diseases, cancer and glomerulosclerosis, wherein V is oxygen or sulfur; W is 1,4-piperazinediyl or 1,4-homopiperazinediyl which may be substituted with unsubstituted alkyl on the ring; X is nitrogen or C-R9, Y is nitrogen or C-R8 and Z is nitrogen or C-R7, with at least one of X, Y and Z being nitrogen; R1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like; R2 is substituted alkyl, substituted or unsubstituted cycloalkyl or the like; R?3, R4, R5 and R6¿ are each independently hydrogen, halogeno, substituted or unsubstituted alkyl, nitro, cyano, -OR?12, -NR15R16¿ or the like; R7 is halogeno or the like; R8 is the same as defined above for R?7; and R9¿ is hydrogen or -COR41.

公开(公告)号：EP1309569B1

公开(公告)日：2010-10-06

申请号：EP01973654.5

申请日：2001-08-17

申请人： MILLENNIUM PHARMACEUTICALS, INC. ,  Kyowa Hakko Kirin Co., Ltd.

发明人： PANDEY, Anjali ,  SCARBOROUGH, Robert, M. ,  MATSUNO, Kenji ,  ICHIMURA, Michio ,  NOMOTO, Yuji ,  IDE, Shinichi ,  TSUKUDA, Eiji ,  IRIE, Junko ,  ODA, Shoji

IPC分类号： C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.