公开(公告)号：EP2463022A1

公开(公告)日：2012-06-13

申请号：EP10806528.5

申请日：2010-08-05

申请人： Kyowakisetsu Co., Ltd. ,  Sunstar Giken Kabushiki Kaisha

发明人： TSUJI, Hideyasu ,  TSUJI, Yasuhiro ,  OKA, Toru ,  SUGI, Shigeru ,  TORII, Masumi ,  MIYAO, Haruka ,  NAKAYAMA, Yoshimitsu ,  TORII, Tomoyuki ,  MORI, Masahito

IPC分类号： B01J13/00 ,  A01M1/20 ,  A01N25/02 ,  A01N43/78 ,  A01P3/00 ,  A61K8/22 ,  A61L9/04 ,  A61Q13/00 ,  B01F3/04 ,  B01F3/08 ,  B01F17/00 ,  C11B9/00 ,  C11D7/24 ,  C11D17/00 ,  C11D17/08

CPC分类号： B01J13/0052 ,  A01N25/04 ,  A01N25/34 ,  A23L2/54 ,  A01N27/00 ,  A01N31/06 ,  A01N43/78 ,  A01N65/26 ,  A01N65/36 ,  A01N65/00

摘要： Disclosed are: a composition which enables the more effective development of the efficacy of a water-soluble drug in a solution containing the drug; and a dispersion in which a hydrophobic drug can be dispersed stably without requiring the use of any surfactant. Specifically disclosed are: a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water; and a process for producing a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water, which utilizes an ultra-fine bubble generation apparatus.

摘要翻译： 公开了一种组合物，其能够更有效地开发含有药物的溶液中的水溶性药物的功效; 以及其中疏水性药物可以稳定分散而不需要使用任何表面活性剂的分散体。 具体公开的是包含模粒径为500nm以下的超细小气泡，药物和水的组合物; 以及利用超微细气泡产生装置制造包含模粒径为500nm以下的超细小气泡，药物和水的组合物的方法。

公开(公告)号：EP2463022B1

公开(公告)日：2018-04-04

申请号：EP10806528.5

申请日：2010-08-05

申请人： LIGARIC CO., LTD. ,  Sunstar Giken Kabushiki Kaisha

发明人： TSUJI, Hideyasu ,  TSUJI, Yasuhiro ,  OKA, Toru ,  SUGI, Shigeru ,  TORII, Masumi ,  MIYAO, Haruka ,  NAKAYAMA, Yoshimitsu ,  TORII, Tomoyuki ,  MORI, Masahito

IPC分类号： B01J13/00 ,  A01M1/20 ,  A01N25/02 ,  A01N43/78 ,  A01P3/00 ,  A61K8/22 ,  A61L9/04 ,  A61Q13/00 ,  B01F3/04 ,  B01F3/08 ,  B01F17/00 ,  C11B9/00 ,  C11D7/24 ,  C11D17/00 ,  C11D17/08

CPC分类号： B01J13/0052 ,  A01N25/04 ,  A01N25/34 ,  A23L2/54 ,  A01N27/00 ,  A01N31/06 ,  A01N43/78 ,  A01N65/26 ,  A01N65/36 ,  A01N65/00

摘要： Disclosed are: a composition which enables the more effective development of the efficacy of a water-soluble drug in a solution containing the drug; and a dispersion in which a hydrophobic drug can be dispersed stably without requiring the use of any surfactant. Specifically disclosed are: a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water; and a process for producing a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water, which utilizes an ultra-fine bubble generation apparatus.