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1.发明公开
公开(公告)号：EP3845237A2
公开(公告)日：2021-07-07
申请号：EP20834993.6
申请日：2020-07-02
发明人： KIM, Jung Min , JIN, Jong Sook , KIM, Shukho
IPC分类号： A61K38/16 , A61P31/04 , A61P31/02 , A01N37/44 , A23L3/3526 , A23C9/152 , A23K20/147
摘要： The present invention relates to the use of the recombinant antibacterial protein Ablysin for effectively killing multidrug-resistant pathogenic bacteria. The recombinant protein Ablysin of the present invention exhibits apoptosis against antibiotic-resistant Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecium to prevent or treat infectious diseases caused by these bacteria and thus it can be widely used in antibiotics, disinfectants, food additives, feed additives, and the like. In particular, the Ablysin uses peptidoglycan, which is a component of the cell wall of bacteria, as a substrate, and exhibits bacterial killing ability due to peptidoglycan degradation. The peptidoglycan exists only in bacteria and not in humans or animals, and thus there is an advantage that Ablysin of the present invention is safe because it does not affect humans and animals, and can be applied to the pharmaceutical industry, food industry, biotechnology, etc., as well as can effectively kill bacteria in a target place or a target substance without problems of resistance to antimicrobial agents.
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2.发明公开
公开(公告)号：EP3821903A1
公开(公告)日：2021-05-19
申请号：EP19859739.5
申请日：2019-08-28
发明人： KIM, Jung Min , JIN, Jong Sook , KIM, Shukho
IPC分类号： A61K38/16 , A61P31/04 , A61P31/02 , C07K14/005 , A23L3/3526 , A23K20/142
摘要： The present invention relates to the use of the recombinant antibacterial enzyme LysSAP26 to effectively kill pathogenic bacteria. LysSAP26, a recombinant protein composed of an amino acid sequence derived from the bacteriophage genome of the present invention, exhibits killing ability against pathogenic bacteria including Acinetobacter baumannii, and thus can prevent or treat infectious diseases caused by these bacteria, and can be widely used in antibiotics, disinfectants, food additives, feed additives, and the like. In particular, the LysSAP26 uses peptidoglycan, which is a component of the cell wall of bacteria, as a substrate, and exhibits bacterial killing ability due to peptidoglycan degradation. The peptidoglycan exists only in bacteria and not in humans or animals, and thus there is an advantage that LysSAP26 of the present invention is safe because it does not affect humans and animals, and can be applied to the pharmaceutical industry, food industry, biotechnology, etc., as well as can effectively kill bacteria in a target place or a target substance without problems of resistance to multi-drug antimicrobial agents.
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3.发明公开
公开(公告)号：EP3795169A1
公开(公告)日：2021-03-24
申请号：EP19797136.9
申请日：2019-04-30
发明人： KIM, Jung Min , KIM, Shukho
IPC分类号： A61K38/16 , A61K48/00 , A23L33/18 , A23K20/147 , C07K14/005 , A61P31/00
摘要： The present invention relates to a bacteriophage-derived recombinant protein having antimicrobial activity against gram-negative bacteria, and the bacteriophage-derived recombinant protein LysSS of the present invention exhibits killing activity to gram-negative bacteria and thus can prevent or treat infectious diseases caused by bacteria, and can be widely used in antibiotics, disinfectants, food additives, feed additives, and the like. In particular, the LysSS uses peptidoglycan, which is a component of the cell wall of bacteria, as a substrate, and exhibits bacterial killing ability due to peptidoglycan degradation and the peptidoglycan exists only in bacteria and not in humans or animals, and thus there is an advantage that LysSS of the present invention is safe because it does not affect humans and animals, and can be applied to the pharmaceutical industry, food industry, biotechnology, etc., as well as can effectively kill bacteria in a target place or a target substance without problems of resistance to multi-drug antimicrobial agents.
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