公开(公告)号：EP0866692A1

公开(公告)日：1998-09-30

申请号：EP96941733.0

申请日：1996-12-10

申请人： LABORATOIRE INNOTHERA Société Anonyme

发明人： BOUTHERIN-FALSON, Odile ,  DESQUAND-BILLIALD, Stéphanie ,  FAVROU, Anita ,  FINET, Michel ,  TEMBO, Olivier ,  TORREGROSA, Jean-luc ,  YANNIC-ARNOULT, Sylvie

IPC分类号： C07D295 ,  A61K31 ,  A61P9 ,  A61P17 ,  A61P19 ,  A61P25 ,  A61P29 ,  C07C225 ,  C07C233 ,  C07C243 ,  C07C275 ,  C07D209 ,  C07D213 ,  C07D215 ,  C07D217 ,  C07D237 ,  C07D239 ,  C07D241 ,  C07D311 ,  C07D319

CPC分类号： C07D213/74 ,  C07C225/30 ,  C07C233/32 ,  C07C243/38 ,  C07C275/30 ,  C07D209/08 ,  C07D213/86 ,  C07D215/24 ,  C07D217/02 ,  C07D237/28 ,  C07D237/30 ,  C07D239/74 ,  C07D241/42 ,  C07D295/116 ,  C07D311/22

摘要： The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is selected from an oxygen atom and a carbonyl grouping; each of R1 and R2 is independently either: a hydrogen atom; or an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring having one or more heteroatoms, a saturated ring optionally having one or more heteroatoms, optionally substituted by an alkyl chain; or a chain having 1-4 atoms, consisting of optionally substituted nitrogen, a carbonyl grouping optionally terminated with an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring optionally having one or more heteroatoms; R3 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, a nitrogen radical substituted by two groupings that are each independently a hydrogen atom or a C1-5 alkyl grouping optionally incorporating a carbonyl grouping, or an aromatic ring; and R4 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, or an optionally substituted oxygen-containing derivative, with the exception of 6-phenylamino-5,8-quinolinedione and 2-N-acetylamino-1,4-naphthoquinone.