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    AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF
    1.
    发明授权
    AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF 失效
    AMINOBENZOPHENONES白细胞介素及TNF抑制剂

    公开(公告)号：EP0966424B1

    公开(公告)日：2004-06-23

    申请号：EP98900270.4

    申请日：1998-01-08

    申请人： LEO PHARMA A/S (with secondary name: LEO PHARMACEUTICAL PRODUCTS LTD. A/S)

    发明人： OTTOSEN, Erik, Rytter ,  RACHLIN, Schneur

    IPC分类号： C07C225/22 ,  A61K31/135

    CPC分类号： C07C225/22

    摘要： The compounds of the present invention are represented by general formula (I) in which formula R1 and R2 stand independently for one or more, similar or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 5, cyano, carboxy, carbamoyl, phenyl, or nitro; R3 stands for hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 5, phenyl, cyano, carboxy, or carbamoyl; R4, R5 and R6 stand independently for hydrogen, trifluoromethyl, alkyl, carbamoyl, alkoxycarbonyl, or alkyloxo, the C-content of which can be from 1 to 5; X stands for oxygen, N-OH, N-O-alkyl, dialkoxy, cyclic dialkoxy, dialkylthio, or cyclic dialkylthio, the C-content of which can be from 1 to 5. The present compounds are of value in the human and veterinary practice as systemic and topical therapeutic agents for the treatment and prophylaxis of asthma, allergy, rheumatoid arthritis, spondyloarthritis, gout, atherosclerosis, chronic inflammatory bowel disease, proliferative and inflammatory skin disorders, such as psoriasis, and atopic dermatitis.