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1.发明公开ANTICORPS ANTI-IDIOTYPIGUES NEUTRALISANT L'ACTIVITE INHIBITRICE D'UN ANTICORPS INHIBITEUR DIRIGE CONTRE LE DOMAINE C1 DU FACTEUR VIII 审中-公开抗独特型抗体的C1结构域的因子VIII抑制的抑制活性抗体展望中性
公开(公告)号：EP2190881A1
公开(公告)日：2010-06-02
申请号：EP07823446.5
申请日：2007-08-23
申请人： LFB Biotechnologies
CPC分类号： C07K16/4241 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also relates to a cell line producing this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to the use thereof for the manufacture of a medicament for the treatment of haemophilia A.
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2.发明公开ANTICORPS ANTI-IDIOTYPIQUES NEUTRALISANT L'ACTIVITE INHIBITRICE D'UN ANTICORPS INHIBITEUR DIRIGE CONTRE LE DOMAINE C1 DU FACTEUR VIII 有权抗独特型抗体，A抑制作用AGAINST C1结构域的因子VIII抑制的效果LOOKING抗体中和的
公开(公告)号：EP1996626A1
公开(公告)日：2008-12-03
申请号：EP07731046.4
申请日：2007-02-26
申请人： LFB Biotechnologies
IPC分类号： C07K16/42 , C12N5/12 , C12N15/13 , A61K39/395 , G01N33/577 , A61P7/04
CPC分类号： C07K16/4241 , A61K2039/505
摘要： The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also to a cell line which produces this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to its use for the manufacture of a medicament for use in the treatment of haemophilia A.
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3.发明授权ANTICORPS ANTI-IDIOTYPIQUES NEUTRALISANT L'ACTIVITE INHIBITRICE D'UN ANTICORPS INHIBITEUR DIRIGE CONTRE LE DOMAINE C1 DU FACTEUR VIII 有权抗独特型抗体，A抑制作用AGAINST C1结构域的因子VIII抑制的效果LOOKING抗体中和的
公开(公告)号：EP1996626B1
公开(公告)日：2011-10-26
申请号：EP07731046.4
申请日：2007-02-26
申请人： LFB Biotechnologies
IPC分类号： C07K16/42 , C12N5/12 , C12N15/13 , A61K39/395 , G01N33/577 , A61P7/04
CPC分类号： C07K16/4241 , A61K2039/505
摘要： The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also to a cell line which produces this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to its use for the manufacture of a medicament for use in the treatment of haemophilia A.
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