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1.发明公开NOVEL PROCESS FOR PREPARING 5-AMINOMETHYL-2-THIOPHENECARBONITRILE. HCL BY ONE-POT REACTION 审中-公开新方法的5-氨基甲基-2-THIOPHENCARBONSÄURENITRIL.HCL在一锅反应制备
公开(公告)号：EP1383758A4
公开(公告)日：2005-10-19
申请号：EP02705581
申请日：2002-03-15
申请人： LG LIFE SCIENCES LTD
发明人： YOON SUK-KYOON , KIM BONG-CHAN , JUNG WON-HYUK , LEE JAE-CHUL , LEE KOO , PARK CHEOL-WON
IPC分类号： C07D333/36 , C07B61/00 , C07D333/38
CPC分类号： C07D333/38
摘要： The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for the thrombin inhibitor may be obtained in a high yield.
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2.发明公开NEW CRYSTALLINE FORMS OF (2S)-N-5-(AMINO(IMINO)METHYL)-2-THIENYLMETHYL-1-(2R)-2-((CARBOXYMETHYL)AMINO)-3,3-DIPHENYLPROPANOYL-2-PYRROLIDINECARBOXAMIDE.nH2O 审中-公开（2S）-N-5-（氨基（亚氨基）甲基）-2-噻吩甲基-1-（2R）-2 - （（羧甲基）氨基）-3,3-二苯基丙酰基-2-吡咯烷基碳酰胺氨基甲酸酯
公开(公告)号：EP1487826A4
公开(公告)日：2005-06-29
申请号：EP03744723
申请日：2003-03-21
申请人： LG LIFE SCIENCES LTD
发明人： KIM AERI , PARK JAE-HYEON , YOON SUK-KYOON , KIM BONG-CHAN , KIM SUNG-JI , CHO KWAN-HYUNG
CPC分类号： C07D409/12 , C07K5/06078 , C07K2299/00
摘要： The present invention relates to crystalline forms of (2S)-N-5-[amino(imino)methyl]-2-thienylmethyl-1-(2R)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nH2O.
摘要翻译： 本发明涉及（2S）-N-5- [氨基（亚氨基）甲基] -2-噻吩基甲基-1-（2R）-2 - [（羧甲基）氨基] -3,3-二苯基丙酰基-2 - 吡咯烷甲酰胺nH 2 O.
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