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1.发明公开(+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF 审中-公开（+） - （1-膦酰-2-烷基环）METHYLNUKLEOSIDDERIVATEN，PROCESS FOR PRODUCING立体异构体的反式异构体，以及由此衍生抗病毒剂USE
公开(公告)号：EP1546164A1
公开(公告)日：2005-06-29
申请号：EP03798577.7
申请日：2003-09-22
发明人： CHOI, Jong-Ryoo,R & D Park, LG Life Sciences Ltd. , HWANG, Jae-Taeg,R & D Park, LG Life Sciences Ltd. , CHO, Dong-Gyu,R & D Park, LG Life Sciences Ltd. , ROH, Kee-Yoon,R & D Park, LG Life Sciences Ltd. , KIM, Chun-Hyung,R & D Park, LG Life Sciences Ltd. , KIM, Chung-Mi,R & D Park, LG Life Sciences Ltd. , HAN, Min-Joon,R & D Park, LG Life Sciences Ltd. , KIM, Jeong-Min,R & D Park, LG Life Sciences Ltd. , CHO, Woo-Young,R & D Park, LG Life Sciences Ltd. , KIM, Gyoung-Won,R & D Park, LG Life Sciences Ltd. , AHN, Sinbyoung,R & D Park, LG Life Sciences Ltd.
IPC分类号： C07F9/6561 , C07F9/6509 , A61K31/675
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
摘要： The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
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