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1.发明公开METHOD FOR PREPARING A (R)- OR (S)- FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE AND A COUNTER ENANTIOMERIC FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE ESTER THERETO USING ENZYME 审中-公开- 形式的N-（2,6-二甲基苯基）丙氨酸，以及使用对映体酶AGAINST N-（2,6-二甲基苯基）丙氨酸酯的一种形式或（S） - 方法呈现的（R）的
公开(公告)号：EP1587943A1
公开(公告)日：2005-10-26
申请号：EP03813309.6
申请日：2003-12-05
发明人： PARK, oh-jin , LEE, Sang Who , PARK, tae-yoon , LEE, Sang Hyun , JOUNG, Won-Kyo , SUH, Byoung-Woo , CHOI, Jeung-soon , JOE, Goonho , CHEONG, Jae Ho
IPC分类号： C12P41/00 , C07C239/08
CPC分类号： C12P41/005 , C12P13/06
摘要： The present invention provides methods for stereospecifically preparing (R)- or (S)-N-(2,6-dimethyl phenyl) alanine and counter ester compounds thereto using enzyme, which comprises reacting an enzyme having hydrolytic activity specific to one enantiomer of racemic (R), (S)-N-(2,6-dimethyl phenyl) alanine esters ((R)-enantiomer and (S)-enantiomer) with the racemic mixture above to obtain (R)- or (S)-N-(2,6-dimethyl phenyl) alanine by optical resolution, or extracting (S)- or (R)-N-(2,6-dimethyl phenyl) alanine ester as an unreacted compound from a reaction mixture using solvent, or esterifying a certain alanine enantiomer separated by the optical resolution with alcohol to synthesize (S)- or (R)-N-(2,6-dimethyl phenyl) alanine ester.
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