公开(公告)号：EP0656883A1

公开(公告)日：1995-06-14

申请号：EP93920406.0

申请日：1993-08-27

申请人： LIFE TECHNOLOGIES, INC.

发明人： GEBEYEHU, Gulilat ,  JESSEE, Joel, A. ,  CICCARONE, Valentina, C. ,  HAWLEY-NELSON, Pamela ,  CHYTIL, Anna

IPC分类号： C12N5 ,  A61K9 ,  A61K47 ,  C07C27 ,  C07C217 ,  C07C219 ,  C07C237 ,  C07C323

CPC分类号： C07C237/10 ,  A61K9/1272 ,  A61K47/543 ,  C07C217/28

摘要： The present invention discloses cationic lipids useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Also disclosed are lipids useful both for the delivery of macromolecules and also useful as intermediates for making other such lipids.

公开(公告)号：EP0656883B1

公开(公告)日：1999-04-07

申请号：EP93920406.1

申请日：1993-08-27

申请人： LIFE TECHNOLOGIES, INC.

发明人： GEBEYEHU, Gulilat ,  JESSEE, Joel, A. ,  CICCARONE, Valentina, C. ,  HAWLEY-NELSON, Pamela ,  CHYTIL, Anna

IPC分类号： C07C217/28 ,  C07C237/10 ,  A61K9/127 ,  A61K47/48 ,  C07C219/06 ,  C07C219/08 ,  C07C323/25

CPC分类号： C07C237/10 ,  A61K9/1272 ,  A61K47/543 ,  C07C217/28

摘要： The present invention discloses cationic lipids useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Also disclosed are lipids useful both for the delivery of macromolecules and also useful as intermediates for making other such lipids.