公开(公告)号：EP0389950A1

公开(公告)日：1990-10-03

申请号：EP90105354.6

申请日：1990-03-21

申请人： LION CORPORATION

发明人： Takeuchi, Takuji ,  Sato, Chikara ,  Oba, Kenkichi ,  Sugiyama, Keikichi

IPC分类号： C07K99/10 ,  C07K5/04 ,  C07K7/04 ,  A61K37/02

CPC分类号： A61K8/64 ,  A61K38/00 ,  A61Q19/02 ,  C07K5/1024 ,  C07K14/685 ,  C07K14/69

摘要： A melanocyte-stimulating hormone inhibitor has an amino acid sequence represented by the following formula [I], [II] or [III] in the molecule:


wherein His, Ser, Arg, Trp, Leu, Ala and Cys represent L- or D-histidine; serine, arginine, tryptophan, leucine, alanine and cysteine residues, respectively. The melanocyte-stimulating hormone inhibitor and an external preparation to be applied to the skin which contains the inhibitor prevent or cure the symptoms of chloasmata and freckles caused by an excess production of melanin by enhanced melanocyte function.

摘要翻译： 黑素细胞刺激激素抑制剂在分子中具有由下式[I]，[II]或[III]表示的氨基酸序列：-His-Ser-Arg-Trp- [I] -Trp-Arg-Ser- His-Ser-Arg，Trp，Leu，Ala和Cys的His- [II] -Leu-Ala-Cys-Ala-Arg- [III]代表L-或D-组氨酸; 丝氨酸，精氨酸，色氨酸，亮氨酸，丙氨酸和半胱氨酸残基。 黑素细胞刺激激素抑制剂和外用制剂，其应用于含有该抑制剂的皮肤，可预防或治愈由增强的黑素细胞功能引起的过量黑色素产生引起的黄褐斑和雀斑的症状。