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1.发明公开Method for preparing a vaccine from Streptococcus mutans for dental caries and vaccinal compositions for dental caries used as nasal drops 失效用于制造用于牙科用品的真菌和用于作为NASAL DROP的牙科用品的VACCINAL组合物的方法
公开(公告)号：EP0400569A3
公开(公告)日：1991-06-05
申请号：EP90110144.4
申请日：1990-05-29
CPC分类号： A61K9/0043 , A61K39/00 , C07K14/315 , Y02A50/472
摘要： A method for preparing a vaccine for dental caries comprises the step of culturing a variant which is obtained by integrating a protein antigen (PAc)-expressing gene into the chromosomal gene of a Streptococcus mutans GS-5 strain to obtain the protein antigen, the protein antigen being produced on the surface of cells of oral Streptococcus mutans or it being extracellularly produced by the microorganism and having a molecular weight ranging from about 170,000 to 220,000. Streptococcus mutans GS-5 (K-3), in which a protein antigen-expressing gene is integrated into the chromosomal gene thereof, has an ability of producing the protein antigen on the surface of the cells or extracellularly. A preventive vaccine composition for dental caries for nasal drops comprises the protein antigen thus produced by the strain: Streptcoccus mutans, the vaccine being intranasally administered. The method makes it possible to enhance the yield of PAc and to simplify processes for purifying PAc. The vaccine composition makes it possible to internally easily absorb the protein antigen, PAc, in high efficiency and it also makes it possible to effectively increase the antibody titer observed after the administration thereof. 1
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2.发明授权Method for preparing a vaccine from Streptococcus mutans for dental caries and vaccinal compositions for dental caries used as nasal drops 失效一种用于变形链球菌的抗龋疫苗的制备和对以滴鼻剂形式龋疫苗组合物的过程。
公开(公告)号：EP0400569B1
公开(公告)日：1995-04-19
申请号：EP90110144.4
申请日：1990-05-29
CPC分类号： A61K9/0043 , A61K39/00 , C07K14/315 , Y02A50/472
摘要： A method for preparing a vaccine for dental caries comprises the step of culturing a variant which is obtained by integrating a protein antigen (PAc)-expressing gene into the chromosomal gene of a Streptococcus mutans GS-5 strain to obtain the protein antigen, the protein antigen being produced on the surface of cells of oral Streptococcus mutans or it being extracellularly produced by the microorganism and having a molecular weight ranging from about 170,000 to 220,000. Streptococcus mutans GS-5 (K-3), in which a protein antigen-expressing gene is integrated into the chromosomal gene thereof, has an ability of producing the protein antigen on the surface of the cells or extracellularly. A preventive vaccine composition for dental caries for nasal drops comprises the protein antigen thus produced by the strain: Streptcoccus mutans, the vaccine being intranasally administered. The method makes it possible to enhance the yield of PAc and to simplify processes for purifying PAc. The vaccine composition makes it possible to internally easily absorb the protein antigen, PAc, in high efficiency and it also makes it possible to effectively increase the antibody titer observed after the administration thereof.
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3.发明公开Method for preparing a vaccine from Streptococcus mutans for dental caries and vaccinal compositions for dental caries used as nasal drops 失效一种用于变形链球菌的抗龋疫苗的制备和对以滴鼻剂形式龋疫苗组合物的过程。
公开(公告)号：EP0400569A2
公开(公告)日：1990-12-05
申请号：EP90110144.4
申请日：1990-05-29
CPC分类号： A61K9/0043 , A61K39/00 , C07K14/315 , Y02A50/472
摘要： A method for preparing a vaccine for dental caries comprises the step of culturing a variant which is obtained by integrating a protein antigen (PAc)-expressing gene into the chromosomal gene of a Streptococcus mutans GS-5 strain to obtain the protein antigen, the protein antigen being produced on the surface of cells of oral Streptococcus mutans or it being extracellularly produced by the microorganism and having a molecular weight ranging from about 170,000 to 220,000. Streptococcus mutans GS-5 (K-3), in which a protein antigen-expressing gene is integrated into the chromosomal gene thereof, has an ability of producing the protein antigen on the surface of the cells or extracellularly. A preventive vaccine composition for dental caries for nasal drops comprises the protein antigen thus produced by the strain: Streptcoccus mutans, the vaccine being intranasally administered. The method makes it possible to enhance the yield of PAc and to simplify processes for purifying PAc. The vaccine composition makes it possible to internally easily absorb the protein antigen, PAc, in high efficiency and it also makes it possible to effectively increase the antibody titer observed after the administration thereof. 1
摘要翻译： 一种制备疫苗用于龋齿的方法包括由INTEGRA婷蛋白质抗原（PAC） - 表达基因导入变异链球菌GS-5菌株的染色体基因，以获得蛋白质抗原，蛋白质获得的培养变体的所有的步骤 抗原被口服变形链球菌细胞表面上产生，或者它被细胞外由所述微生物产生和具有分子量为约17万至22万。 变形链球菌GS-5（K-3）中，其中的蛋白质抗原表达基因整合到染色体基因体，具有产生细胞或细胞外的表面上的蛋白质抗原的能力。 龋齿为滴鼻剂预防性疫苗组合物包含蛋白质抗原由应变如此产生：Streptcoccus变形链球菌，疫苗被鼻内施用。 该方法使得有可能提高PAC的收率和简化工艺用于纯化的PAC。 所述疫苗组合物能够在内部容易地吸收蛋白质抗原，PAC在高效率，因此使得有可能有效地增加其给药后的抗体效价观察。
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