公开(公告)号：EP3200878A4

公开(公告)日：2018-05-30

申请号：EP15847978

申请日：2015-10-05

申请人： LOS ALAMOS NAT SECURITY LLC ,  UNIV OREGON HEALTH & SCIENCE ,  VIR BIOTECHNOLOGY INC

发明人： BRUENING ERIC ,  FRUEH KLAUS ,  PICKER LOUIS ,  KORBER BETTE T M ,  THEILER JAMES ,  MARSHALL EMILY

IPC分类号： A61P31/18 ,  A61K39/21

CPC分类号： A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/70 ,  C12N2710/16143 ,  C12N2740/16034 ,  C12N2740/16234

摘要： Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.