公开(公告)号：EP1594527A2

公开(公告)日：2005-11-16

申请号：EP04708229.2

申请日：2004-02-04

申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH ,  Licentia, Ltd. ,  Flanders Interuniversity Institute for Biotechnology (VIB)

发明人： ALITALO, Kari,University of Helsinki ,  ERIKSSON, Ulf,Ludwig Inst. for Cancer Research ,  CARMELIET, Peter,C. for Transgene Tech. & Gene T. ,  LI, Xuri,c/o Ludwig Institute for Cancer Research ,  COLLEN, Desire,C. for Transgene Tech. & Gene T. ,  YLA-HERTTUALA, Seppo,University of Kuopio ,  SALVEN, Petri,University of Helsinki ,  RAJANTIE, Iiro,c/o University of Helsinki

IPC分类号： A61K38/18 ,  A61K38/19 ,  A61P9/10 ,  A61P7/00

CPC分类号： A61K38/193 ,  A61K35/545 ,  A61K38/18 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/202 ,  A61K48/00 ,  A61K48/005 ,  C12N15/86 ,  C12N2710/10343 ,  A61K2300/00

摘要： The present invention provides materials and methods for VEGF-B and PDGF therapy, especially therapy directed at stem cell recruitment, proliferation, and/or differentiation.

公开(公告)号：EP1581241A2

公开(公告)日：2005-10-05

申请号：EP02761012.0

申请日：2002-06-20

申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH ,  Flanders Interuniversity Institute for Biotechnology (VIB)

发明人： ERIKSSON, Ulf,Ludwig Inst. for Cancer Research ,  LI, Xuri,Ludwig Institute for Cancer Research ,  CARMELIET, Peter,Flanders Int. Inst. for Biotech. ,  COLLEN, Desire,Flanders Int. Inst. for Biotech.

IPC分类号： A61K38/00 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K38/1825 ,  A61K38/1858 ,  A61K38/1866 ,  A61K48/00 ,  C12N2710/10343

摘要： VEGF-B is shown to be needed for cardiac muscle revascularization after heart infarction, and methods of promoting or stimulating vascular development, e.g. angiogenesis and/or arteriogenesis, particularly in ischemic mammals, are disclosed.