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1.发明公开5HT7 receptor ligands and compositions comprising the same 审中-公开5HT7-Rezeptorliganden和Zusammensetzungen damit
公开(公告)号：EP2149373A1
公开(公告)日：2010-02-03
申请号：EP08380239.7
申请日：2008-08-01
IPC分类号： A61K31/495 , A61K31/496 , A61K31/506 , A61K31/515 , A61P9/00 , A61P13/00 , A61P25/00
CPC分类号： A61K31/495 , A61K31/496 , A61K31/506 , A61K31/515
摘要： The present invention relates to compounds having pharmacological activity towards the 5-HT 7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT 7 is involved, such as CNS disorders.
摘要翻译： 本发明涉及具有针对5-HT 7受体的药理学活性的化合物，特别是作为通过使用药效团和描述符轮廓过滤器鉴定的激动剂以及包含它们的药物组合物。 这些化合物特别用于治疗和/或预防其中涉及5-HT 7的疾病，例如CNS疾病。
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2.发明公开Method for screening of 5HT7 receptor ligands based on a new pharmacophore model and a descriptor's profile filter 审中-公开基于新的药效团模型和描述符分布过滤器筛选5HT7受体配体的方法
公开(公告)号：EP2151777A1
公开(公告)日：2010-02-10
申请号：EP08380240.5
申请日：2008-08-01
IPC分类号： G06F19/00
CPC分类号： G06F19/705 , A61K31/4045 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , G06F19/706
摘要： The present invention relates to compounds having pharmacological activity towards the 5-HT 7 receptor; to a method for identifying them as 5-HT 7 ligands, especially as agonists, by using a pharmacophore and a descriptor's profile filter; to pharmaceutical compositions comprising them; and to their use in therapy, in particular for the treatment and or prophylaxis of a disease in which 5-HT 7 is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物; 涉及通过使用药效基团和描述符分布过滤器将它们鉴定为5-HT 7配体，特别是作为激动剂的方法; 包含它们的药物组合物; 并涉及它们在治疗中的用途，特别是用于治疗和/或预防其中涉及5-HT 7的疾病如CNS病症的用途。
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