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公开(公告)号：EP4180045A1
公开(公告)日：2023-05-17
申请号：EP20952613.6
申请日：2020-09-02
发明人： OLLERVIDES RUBIO, Paola Yazmín , ESPINOZA LEÓN, Sixto Serafín , CUAHUTENCOS ESCOBAR, Ernesto , GONZÁLEZ CANUDAS, Jorge Alejandro
IPC分类号： A61K31/64 , A61K31/155 , A61K31/401 , A61P3/10
摘要： This invention relates to an innovative stable immediate release drug for the treatment, control, and better management of type 2 diabetes mellitus containing a sulfonylurea such as glimepiride, a dipeptidyl peptidase-4 (DPP4) inhibitor such as vildagliptin, and a biguanidine such as metformin. At the same time, this invention allows solving a set of important technological challenges in the manufacture of said drug product due to the physicochemical properties and the difference in dosage of the synergistic combination of the drugs.
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公开(公告)号：EP4230211A1
公开(公告)日：2023-08-23
申请号：EP20964393.1
申请日：2020-12-04
发明人： MUÑOZ MARTINEZ, Cecilia Jannette , FARFÁN SALAZAR, Claudia Delfina , ESPINOZA LEÓN, Sixto Serafín , GONZÁLEZ CANUDAS, Jorge Alejandro , OLLERVIDES RUBIO, Paola Yazmín
IPC分类号： A61K31/573 , A61K31/4545 , A61P37/08
摘要： The present invention combines in only one dosage unit the drugs desloratadine and betamethasone, which represents a set of important technological challenges due to the physicochemical properties and the difference in dosage to ensure the obtaining of a stable product for the treatment of allergic and inflammatory processes in a subject.
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3.发明公开
公开(公告)号：EP4230199A1
公开(公告)日：2023-08-23
申请号：EP20964395.6
申请日：2020-12-04
发明人： MUÑOZ MARTÍNEZ, Cecilia Jannette , GONZÁLEZ CANUDAS, Jorge Alejandro , OLLERVIDES RUBIO, Paola Yazmín , ESPINOZA LEÓN, Sixto Serafín , CUAHUTENCOS ESCOBAR, Ernesto
IPC分类号： A61K31/197 , A61K31/137 , A61P25/04
摘要： This invention comprises pharmaceutical compositions consisting of tramadol and pregabalin, or a pharmaceutically acceptable salt thereof, for the treatment of neuropathic pain. Besides offering an analgesic effect and a decrease of adverse events due to the reduced dose of one or both compounds, it has an improved stability, thus maintaining the dissolution and bioavailability of the composition to be administered. The composition manages to overcome the technological difficulty of having two humidity- and light-sensitive drugs in a dispensing medium that does not affect their absorption by means of a water-free process and a light protection coating without affecting the release of both drugs.
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4.发明公开
公开(公告)号：EP3680252A1
公开(公告)日：2020-07-15
申请号：EP17927999.7
申请日：2017-10-02
发明人： GONZÁLEZ CANUDAS, Jorge Alejandro , GARCÍA UBBELOHDE, Walter Jacob , ROSAS ROMERO, Gabriel , RIVERA MARTÍNEZ, Vicente
IPC分类号： C07K16/18
摘要： The present invention relates to the field of products of biological origin based on fragmentation of antibodies that are used for passive immunization to neutralize toxins present in poisonous animal venoms, specifically it refers to a biological product where the active ingredient is a combination of F(ab') 2 antibody fragments and the process to obtain thereof with a higher yield and better quality in terms of purity and neutralizing capacity of such toxins. Its purification from hyperimmune plasma by salting out without cresol, thermocoagulation and dialysis and applying ultrafiltration techniques with specific parameters is described in order to obtain F(ab') 2 fragments with purities greater than 95%.
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公开(公告)号：EP4268813A1
公开(公告)日：2023-11-01
申请号：EP20964394.9
申请日：2020-12-04
发明人： MUÑOZ MARTÍNEZ, Cecilia Jannette , GONZÁLEZ CANUDAS, Jorge Alejandro , OLLERVIDES RUBIO, Paola Yazmín , ESPINOZA LEÓN, Sixto Serafín , FARFÁN SALAZAR, Claudia Delfina
IPC分类号： A61K31/192 , A61K31/51 , A61K31/4415 , A61K31/714 , A61P29/00
摘要： This invention is about the manufacture of fixed-dose combination drug products to be used as an anti-inflammatory and antineuritic agents for the control and management of pain, particularly moderate to severe intensity acute pain of different etiologies resulting from peripheral neuropathies, low back pain, sciatica, neck pain, radiculitis, post-herpetic neuralgia, spondylitis, carpal tunnel syndrome, fibromyalgia, etc., of different etiologies such as inflammatory, drug, diabetic, alcoholic, or nutritional etiology, etc. These fixed-dose combination drug products contain a therapeutically effective amount of (a) a non-steroidal anti-inflammatory drug (NSAID) or a pharmaceutically acceptable salt thereof, (b) an antineuritic agent or a pharmaceutically acceptable salt thereof, and (c) at least one pharmaceutically acceptable amount of a pharmaceutically acceptable excipient.
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6.发明公开
公开(公告)号：EP4226923A1
公开(公告)日：2023-08-16
申请号：EP20964396.4
申请日：2020-12-04
发明人： GONZÁLEZ CANUDAS, Jorge Alejandro , MUÑOZ MARTÍNEZ, Cecilia Jannette , OLLERVIDES RUBIO, Paola Yazmín , ESPINOZA LEÓN, Sixto Serafín , MÁRQUEZ MEJÍA, Jannette
IPC分类号： A61K31/435 , A61K31/192 , A61P11/00
摘要： This invention involves an improved, immediate-release pharmaceutical composition against respiratory diseases and acute upper respiratory tract infections (IAVRS) with a stable bioavailability and comprises an analgesic, such as ibuprofen; an antihistamine, such as loratadine; and one or more excipients, such as suspending agents, solubilizers, co-solvents, sweeteners or flavorings, colorants, preservatives or antimicrobials, and solvents. The manufacturing process of the composition manages to overcome the technological complexity of having both drugs in liquid form while preserving their physicochemical properties.
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公开(公告)号：EP4180036A1
公开(公告)日：2023-05-17
申请号：EP20956398.0
申请日：2020-09-29
发明人： OLLERVIDES RUBIO, Paola Yazmín , GONZÁLEZ CANUDAS, Jorge Alejandro , ESPINOZA LEÓN, Sixto Serafín , FARFÁN SALAZAR, Claudia Delfina
IPC分类号： A61K31/40 , A61K31/216 , A61P3/06
摘要： This invention combines in a single dosage form the active principles, atorvastatin and fenofibrate, which represents a set of important technological challenges due to the physicochemical properties and the difference in dosage to ensure obtaining a stable product in the treatment of hyperlipidemia and the prevention of cardiovascular diseases.
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