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1.发明授权DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权9 AMINOPODOPHYLLOTOXINDERIVATE，其制备方法和药物组合物含有这些衍生物
公开(公告)号：EP1664055B9
公开(公告)日：2007-10-10
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
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2.发明公开DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权9 AMINOPODOPHYLLOTOXINDERIVATE，其制备方法和药物组合物含有这些衍生物
公开(公告)号：EP1664055A1
公开(公告)日：2006-06-07
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
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3.发明授权DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权DER 9-AMINO-PODOPHYLLOXOXINE，LEUR PROCEDE DE PREPARATION ET LES组合物药物组合物QUI LES CONTIENNENT
公开(公告)号：EP1664055B1
公开(公告)日：2006-12-13
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译： 烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基， 膦酸和Si（Ra）2Rb，Y是选自HN-NH和NR 2的基团，R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体 及其盐。
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