公开(公告)号：EP3239717A1

公开(公告)日：2017-11-01

申请号：EP17173498.1

申请日：2011-04-11

申请人： Leukodx Ltd

发明人： KASDAN, Harvey Lee ,  RAJUAN, Menashe ,  BRODER, Yehoshua ,  MEISSONNIER, Julien ,  DAVIS, Bruce ,  ZUTA, Yoav

IPC分类号： G01N35/00 ,  G01N33/48 ,  G01N21/62 ,  G01N21/76 ,  G01N21/64 ,  G01N33/50

摘要： The present invention provides a system and method for determination of a medical condition, the system including a disposable cartridge adapted to receive a volume of a body fluid, the cartridge comprising a plurality of sections, at least one of the sections adapted to react at least one reactant with the bodily fluid to form a pre-treated sample; and an optics unit comprising at least one excitation illumination adapted to convey radiation to the pre-treated sample, at least one multi-spectral emission detector and at least one of a photon counter and an integrator, wherein the at least one excitation illumination and the at least one multi-spectral emission detector are disposed on the same side of the cartridge; and wherein the optics unit is adapted to detect a plurality of spectrally distinct signals generated by interaction of the radiation and the pre-treated sample in the cartridge, thereby determining said medical condition.

摘要翻译： 本发明提供了一种用于确定医疗状况的系统和方法，所述系统包括适于接收一定体积的体液的一次性药筒，所述药筒包括多个区段，所述区段中的至少一个适于至少反应 一种反应物与体液混合以形成预处理的样品; 以及光学单元，其包括适于将辐射传送到预处理样本的至少一个激发照明，至少一个多光谱发射检测器以及光子计数器和积分器中的至少一个，其中所述至少一个激发照明和 至少一个多光谱发射检测器设置在盒的相同侧上; 并且其中所述光学单元适于检测由所述辐射和所述盒中的所述预处理样品的相互作用产生的多个光谱不同的信号，由此确定所述医疗状况。

公开(公告)号：EP3304040A1

公开(公告)日：2018-04-11

申请号：EP16799468.0

申请日：2016-05-23

申请人： Leukodx Ltd

发明人： KASDAN, Harvey Lee

IPC分类号： G01N15/14 ,  G01N21/64

CPC分类号： G01N15/1459 ,  G01N15/1429 ,  G01N2015/1006

摘要： Determining total particle emission of a flow cytometer particle by passing laser excitation energy into a generally perpendicular flow cytometer channel element through which a particle passes, the particle adapted to be irradiated and to emit a fluorescent emission responsive to the laser excitation energy, where the fluorescent emission results from a geometrical convolution of a geometrical form of the laser excitation energy and a geometric characteristic of a fluorescent emission of the particle, detecting any of the fluorescent emission, outputting an analog electrical emission, providing multiple time samples of the analog electrical emission, and processing the multiple time samples to calculate a total fluorescent emission of said particle, by determining the extent of said geometric convolution and fitting said time samples to a function of a same extent.