公开(公告)号：EP2822559B1

公开(公告)日：2018-05-02

申请号：EP13712953.2

申请日：2013-03-05

申请人： Lexicon Pharmaceuticals, Inc.

发明人： BI, Yingzhi ,  CARSON, Kenneth Gordon ,  CIANCHETTA,Giovanni ,  GREEN, Michael Alan ,  KUMI, Godwin ,  LIANG, Zhi ,  LIU, Ying Jade ,  MAIN, Alan ,  ZHANG, Yulian ,  ZIPP, Glenn Gregory

IPC分类号： A61K31/5025 ,  A61P25/28 ,  A61P29/00 ,  A61P25/24

CPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D241/04 ,  C07D401/14 ,  C07D403/14 ,  C07D498/18 ,  C07D519/00

摘要： Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

公开(公告)号：EP2822559A1

公开(公告)日：2015-01-14

申请号：EP13712953.2

申请日：2013-03-05

申请人： Lexicon Pharmaceuticals, Inc.

发明人： BI, Yingzhi ,  CARSON, Kenneth Gordon ,  CIANCHETTA,Giovanni ,  GREEN, Michael Alan ,  KUMI, Godwin ,  LIANG, Zhi ,  LIU, Ying Jade ,  MAIN, Alan ,  ZHANG, Yulian ,  ZIPP, Glenn Gregory

IPC分类号： A61K31/5025 ,  A61P25/28 ,  A61P29/00 ,  A61P25/24

CPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D241/04 ,  C07D401/14 ,  C07D403/14 ,  C07D498/18 ,  C07D519/00

摘要： Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

摘要翻译： 公开了式（I）的基于咪唑并[1,2-b]哒嗪的化合物：其中R 1，R 2和R 3如本文所定义。 还公开了包含所述化合物的组合物及其用于治疗，管理和/或预防由衔接子相关激酶1活性介导介导的疾病和病症的方法。

公开(公告)号：EP2834243B1

公开(公告)日：2018-04-25

申请号：EP13710250.5

申请日：2013-03-05

申请人： Lexicon Pharmaceuticals, Inc.

发明人： BI, Yingzhi ,  CARSON, Kenneth Gordon ,  CIANCHETTA, Giovanni ,  GREEN, Michael Alan ,  KUMI, Godwin ,  MAIN, Alan ,  ZHANG, Yulian ,  ZIPP, Glenn Gregory

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/16 ,  A61P25/28 ,  A61P25/18

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07B59/002 ,  C07B2200/05

摘要： are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

公开(公告)号：EP2834243A1

公开(公告)日：2015-02-11

申请号：EP13710250.5

申请日：2013-03-05

申请人： Lexicon Pharmaceuticals, Inc.

发明人： BI, Yingzhi ,  CARSON, Kenneth Gordon ,  CIANCHETTA, Giovanni ,  GREEN, Michael Alan ,  KUMI, Godwin ,  MAIN, Alan ,  ZHANG, Yulian ,  ZIPP, Glenn Gregory

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/16 ,  A61P25/28 ,  A61P25/18

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07B59/002 ,  C07B2200/05

摘要： are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

摘要翻译： 并[1,5-A]下式的嘧啶基的化合物：是游离缺失光盘，worin R1，R2和R3中所定义。 组合物包含所述化合物和它们的使用来治疗的方法，用于管理和/或预防由适配器相关激酶1活性介导的疾病和病症是游离缺失盘。