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1.发明公开A NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP 有权神经系统ZUR VERABREICHUNG VON ARZNEIMITTELN AUF DER GRUNDLAGE VON JCV-VLP
公开(公告)号：EP2823048A1
公开(公告)日：2015-01-14
申请号：EP13714195.8
申请日：2013-03-06
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
摘要： The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
摘要翻译： 本发明涉及来自装载有药物（货物）的人多瘤病毒作为药物递送系统的VLP，用于将所述药物转运到CNS中，特别是活的人。
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公开(公告)号：EP2739725B1
公开(公告)日：2019-11-06
申请号：EP12753905.4
申请日：2012-08-01
发明人： DEMINA, Victoria , MANNINGA, Heiko
IPC分类号： C12N7/02 , C12N7/04 , C07K14/025 , C07K14/005
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公开(公告)号：EP2823048B1
公开(公告)日：2017-11-08
申请号：EP13714195.8
申请日：2013-03-06
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
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公开(公告)号：EP2739725A1
公开(公告)日：2014-06-11
申请号：EP12753905.4
申请日：2012-08-01
发明人： DEMINA, Victoria , MANNINGA, Heiko
IPC分类号： C12N7/02 , C12N7/04 , C07K14/025 , C07K14/005
摘要： The invention relates to a method for purifying compositions containing virus-like particles (VLP), wherein a VLP-containing composition is filtered through a filter medium, in particular through a membrane, having a molecular weight cut off (MWCO) of more than 30 kDa, and the cell culture supernatant of VLP-expressing cells is used as a VLP-containing composition. The invention further relates to a VLP-containing composition which can be produced by this method.
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