公开(公告)号：EP4286531A2

公开(公告)日：2023-12-06

申请号：EP23187659.0

申请日：2019-03-22

申请人： Life Technologies Corporation

发明人： Looney, Timothy

IPC分类号： C12Q1/6806

摘要： The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, methods provide for determining convergence of T cell receptor and/or B cell receptor repertoires in samples prior to a treatment and predicting a subject's response to the treatment based on the measured convergence frequency. In another aspect, methods provide for an immune receptor haplotype group and predicting a subject's potential or predisposition to be protected from or vulnerable to an adverse event following a treatment.

公开(公告)号：EP4286531A3

公开(公告)日：2024-01-17

申请号：EP23187659.0

申请日：2019-03-22

申请人： Life Technologies Corporation

发明人： Looney, Timothy

IPC分类号： C12Q1/6886 ,  C12Q1/6806

摘要： The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, methods provide for determining convergence of T cell receptor and/or B cell receptor repertoires in samples prior to a treatment and predicting a subject's response to the treatment based on the measured convergence frequency. In another aspect, methods provide for an immune receptor haplotype group and predicting a subject's potential or predisposition to be protected from or vulnerable to an adverse event following a treatment.