公开(公告)号：EP3521315A1

公开(公告)日：2019-08-07

申请号：EP19163818.8

申请日：2013-05-24

申请人： LifeArc

发明人： JOHNSON, Tim ,  WATSON, Phil ,  MATTHEWS, David ,  BROWN, Alex

IPC分类号： C07K16/40 ,  A61K39/00 ,  A61K51/10

摘要： The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

公开(公告)号：EP2855530B1

公开(公告)日：2019-05-01

申请号：EP13730049.7

申请日：2013-05-24

申请人： LifeArc

发明人： JOHNSON, Tim ,  WATSON, Phil ,  MATTHEWS, David ,  BROWN, Alex

IPC分类号： C07K16/40