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公开(公告)号:EP3473278A1
公开(公告)日:2019-04-24
申请号:EP18209569.5
申请日:2012-04-27
申请人: LifeCell Corporation
发明人: CHEN, Yi
摘要: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix.
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公开(公告)号:EP4438069A2
公开(公告)日:2024-10-02
申请号:EP24181813.7
申请日:2014-09-05
申请人: LifeCell Corporation
发明人: CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号: A61L27/36
CPC分类号: A61L27/3633 , A61L27/3687 , A61L27/3695
摘要: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
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公开(公告)号:EP2701755B1
公开(公告)日:2019-01-16
申请号:EP12720056.6
申请日:2012-04-27
申请人: LifeCell Corporation
发明人: CHEN, Yi
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公开(公告)号:EP3030272A1
公开(公告)日:2016-06-15
申请号:EP14776766.9
申请日:2014-09-05
申请人: Lifecell Corporation
发明人: CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号: A61L27/36
CPC分类号: A61L27/3687 , A61L27/3633 , A61L27/3695
摘要: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen- containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
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公开(公告)号:EP3473278B1
公开(公告)日:2020-10-28
申请号:EP18209569.5
申请日:2012-04-27
申请人: LifeCell Corporation
发明人: CHEN, Yi
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公开(公告)号:EP3030272B1
公开(公告)日:2019-05-29
申请号:EP14776766.9
申请日:2014-09-05
申请人: LifeCell Corporation
发明人: CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号: A61L27/36
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公开(公告)号:EP3468629A1
公开(公告)日:2019-04-17
申请号:EP17733669.0
申请日:2017-06-09
申请人: LifeCell Corporation
发明人: XU, Hui , COLLINS, Sean , HUANG, Li, Ting , WAN, Hua , CHEN, Yi
IPC分类号: A61L27/24
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公开(公告)号:EP2701755A1
公开(公告)日:2014-03-05
申请号:EP12720056.6
申请日:2012-04-27
申请人: Lifecell Corporation
发明人: CHEN, Yi
CPC分类号: A61L27/3687 , A61L27/3604 , A61L27/362 , A61L27/3662 , A61L27/3695 , A61L27/56 , A61L2430/40 , C12P1/00
摘要: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix.
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公开(公告)号:EP4052735A1
公开(公告)日:2022-09-07
申请号:EP22169285.8
申请日:2014-09-05
申请人: LifeCell Corporation
发明人: CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号: A61L27/36
摘要: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
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公开(公告)号:EP3549616A1
公开(公告)日:2019-10-09
申请号:EP19174739.3
申请日:2014-09-05
申请人: LifeCell Corporation
发明人: CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号: A61L27/36
摘要: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
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