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    USE OF XIKVAV PEPTIDES IN THE PREPARATION OF COSMETIC COMPOSITIONS WHICH ARE INTENDED TO IMPROVE THE FIRMNESS OF THE SKIN BY INCREASING CELL ADHESION
    1.
    发明公开
    USE OF XIKVAV PEPTIDES IN THE PREPARATION OF COSMETIC COMPOSITIONS WHICH ARE INTENDED TO IMPROVE THE FIRMNESS OF THE SKIN BY INCREASING CELL ADHESION 有权
    XIKVAV肽的化妆品组合物的生产中使用用于改善皮肤抗性增加细胞粘附

    公开(公告)号：EP1741421A1

    公开(公告)日：2007-01-10

    申请号：EP05731868.5

    申请日：2005-04-05

    申请人： Lipotec, S.A.

    发明人： ALMIÑANA DOMENECH, Nuria ,  GARCIA ANTON, José María ,  CEBRIÁN PUCHE, Juan ,  PUIG MONTIEL, Arturo

    IPC分类号： A61K8/18

    CPC分类号： A61Q19/08 ,  A61K8/64

    摘要： The invention relates to cosmetic compositions which are intended to improve the firmness of the skin by increasing adhesion of cutaneous cells in relation to one another and the basal lamina. The aforementioned compositions comprise a cosmetically-effective quantity of peptides having general formula X-isoleucyl-lysyl-valyl-alanyl-valine-Y, known as XIKVAV (figure 1). The invention also relates to the use of XIKVAV peptides in the preparation of cosmetic compositions which are intended to improve the firmness of the skin.

    摘要翻译： 本发明涉及其旨在通过相对于增加彼此和基底膜皮肤细胞的粘附改善皮肤的牢固性化妆品组合物。 上述组合物包含具有通式X-异亮赖氨酰缬氨酰 - 丙氨酰 - 缬氨酸 - Y，称为XIKVAV（图1）的肽的美容上有效量。 因此，本发明涉及在其旨在改善皮肤的坚实度的化妆品组合物的制备中的用途XIKVAV肽。

    DERMOPHARMACEUTICAL OR COSMETIC COMPOSITION COMPRISING ENKEPHALIN-DERIVED PEPTIDES FOR REDUCING AND/OR ELIMINATING FACIAL WRINKLES
    5.
    发明公开
    DERMOPHARMACEUTICAL OR COSMETIC COMPOSITION COMPRISING ENKEPHALIN-DERIVED PEPTIDES FOR REDUCING AND/OR ELIMINATING FACIAL WRINKLES 有权
    脑啡肽衍生肽含皮肤用药物或化妆品组合物用于减少和/或消除面部皱纹

    公开(公告)号：EP1892247A1

    公开(公告)日：2008-02-27

    申请号：EP06725832.7

    申请日：2006-03-29

    申请人： Lipotec, S.A.

    发明人： FERRER MONTIEL, Antonio ,  CEBRIAN PUCHE, Juan ,  PUIG MONTIEL, Arturo

    IPC分类号： C07K7/06

    CPC分类号： A61Q19/08 ,  A61K8/64 ,  A61K38/00 ,  C07K14/70

    摘要： The invention relates to a cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides for reducing and/or eliminating facial wrinkles.
    Said cosmetic or dermopharmaceutical composition for application in the skin, preferably in the skin of the face, to reduce and/or eliminate facial wrinkles, preferably facial expression wrinkles and comprises a cosmetically or dermopharmaceutically effective amount of a peptide of general formula (I).
    The invention also relates to the use of the peptide of general formula (I) in the preparation of a cosmetic or dermopharmaceutical composition reducing and/or eliminating facial wrinkles.

    摘要翻译： 本发明涉及化妆品或皮肤用药物组合物，包括脑啡肽衍生肽用于减少和/或消除面部皱纹。 施用于皮肤，所述化妆品或皮肤用药物组合物，优选在面部的皮肤上，以减少和/或消除面部皱纹，优选面部表情皱纹和包含美容或皮肤用药物学有效量的通式（I）的肽。 因此，本发明涉及使用在化妆品或皮肤用药物组合物，减少和/或消除面部皱纹的制备通式（I）的肽。

    SYNTHETIC PEPTIDES USED FOR TREATING THE SKIN AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS
    6.
    发明公开
    SYNTHETIC PEPTIDES USED FOR TREATING THE SKIN AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS 有权
    用于皮肤护理使用的合成肽及它们在美容或皮肤用药物组合物

    公开(公告)号：EP2025681A2

    公开(公告)日：2009-02-18

    申请号：EP07730420.2

    申请日：2007-03-30

    申请人： Lipotec, S.A.

    发明人： ALMIÑANA DOMENECH, Nuria ,  VAN DEN NEST, Will ,  CARREÑO SERRAIMA, Cristina ,  CEBRIAN PUCHE, Joan ,  PASSERINI, Elena ,  PUIG MONTIEL, Arturo

    IPC分类号： C07K5/10

    CPC分类号： A61K8/64 ,  A61K2800/522 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/1019

    摘要： The present invention relates to peptides of general formula (I) capable of regulating fibrillogenesis, stereoisomers thereof and mixtures thereof, which may or may not be racemic, and the cosmetically or dermopharmaceutically acceptable salts thereof, wherein Z is alanyl, allo -isoleucyl, glycyl, isoleucyl, isoseryl, isovalyl, leucyl, norleucyl, norvalyl, prolyl, seryl, threonyl, allo -threonyl or valyl; n and m may vary between 1 and 5; AA is selected from the group consisting of natural amino acids encoded in their L- or D- form and non-encoded amino acids; x and y may vary between 0 and 2; R 1 is H or alkyl, aryl, aralkyl or acyl group; and R 2 is amino, hydroxyl or thiol, all of them substituted or non-substituted with aliphatic or cyclic groups. A method for obtaining cosmetic or dermopharmaceutical compositions containing them and use thereof for treating the skin, preferably those skin conditions which require regulating fibrillogenesis, such as aging and/or the softening of the appearance of scars.

    摘要翻译： 本发明涉及一种能够调节原纤维形成其，立体异构体以及它们的混合物的通式（I）的肽，其可以是或可以不是外消旋的，并且其美容或皮肤用药物学可接受的盐，worin Z是丙氨酰基，别-isoleucyl，甘氨酰 ，异亮，isoseryl，isovalyl，亮氨酰，正亮氨酰基，norvalyl，脯氨酰，丝氨酰，苏氨酰，别-threonyl或缬氨酰基; n和m可以1和5之间变化; AA是选自在它们的L-或D-形式和非编码的氨基酸编码的天然氨基酸中选择; x和y可在0和2之间变化; R 1为H或烷基，芳基，芳烷基或酰基; R 2为氨基，羟基或硫醇基，它们全部substituiertem或非substituiertem与脂族或环状基团。 一种用于获得化妆品或皮肤用药物组合物含有它们及其用于治疗皮肤，优选皮肤需要调节原纤维形成，：如老化和/或疤痕外观的软化这些条件的方法。

    SYNTHETIC PEPTIDES WHICH REDUCE OR ELIMINATE BAGS FORMED UNDER THE LOWER RIM OF THE EYES AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS
    8.
    发明公开
    SYNTHETIC PEPTIDES WHICH REDUCE OR ELIMINATE BAGS FORMED UNDER THE LOWER RIM OF THE EYES AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS 有权
    合成肽，以减少或眼睛下边框使用列在美容或皮肤用药物组合物袋REMOVAL

    公开(公告)号：EP1798238A1

    公开(公告)日：2007-06-20

    申请号：EP05799175.4

    申请日：2005-09-22

    申请人： Lipotec, S.A.

    发明人： PUIG MONTIEL, Arturo ,  CEBRIAN PUCHE, Juan ,  PASSERINI, Elena

    IPC分类号： C07K5/103 ,  A61K38/07 ,  A61P7/10

    CPC分类号： A61K38/07 ,  A61K8/64 ,  A61K31/4178 ,  A61Q1/02 ,  A61Q1/14 ,  A61Q19/00 ,  C07K5/0202 ,  C07K5/10

    摘要： The invention relates to peptides of general formula (I):

    that can reduce or remove bags formed under the eyes, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or dermopharmaceutically acceptable salts thereof, wherein X is cystenyl, seryl, threonyl or aminobutyryl; R 1 is H or alkyl, aryl, aralkyl or acyl group; and R 2 is amino, hydroxy or thiol, all of them substituted or non-substituted with aliphatic or cyclic groups. The invention also relates to a method of obtaining, cosmetic or dermopharmaceutical compositions containing them and their use for treating skin, preferably for reducing or removing bags formed under the eyes.

    摘要翻译： 本发明涉及通式（I）的肽：其可以减少或消除眼袋，其立体异构体和外消旋或非外消旋混合物或其形成，并且所述化妆品或皮肤用药物学可接受的盐，worin X是cystenyl，丝氨酰， 苏氨基丁或; R 1为H或烷基，芳基，芳烷基或酰基; R 2为氨基，羟基或硫醇基，它们全部substituiertem或非substituiertem与脂族或环状基团。 因此，本发明涉及含有它们和它们用于治疗皮肤，优选用于减少或去除下形成的眼袋使用获取，化妆品或皮肤用药物组合物的方法。