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    PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES
    1.
    发明公开
    PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES 有权
    PROCESS FOR循环氨基甲酸酯的合成

    公开(公告)号：EP2627643A1

    公开(公告)日：2013-08-21

    申请号：EP11773190.1

    申请日：2011-10-14

    申请人： Lonza Ltd

    发明人： BRENNER, Meinrad ,  CARREIRA, Erick, M. ,  CHINKOV, Nicka ,  LORENZI, Miriam ,  WARM, Aleksander ,  ZIMMERMANN, Lothar

    IPC分类号： C07D265/18

    CPC分类号： C07D265/18

    摘要： The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C
    2-5 -alkyl C
    2-5 -carboxylates and mixtures of at least one C
    2-5 -alkyl C
    2-5 -carboxylate with at least one C
    5-8 -alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided.

    PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES
    3.
    发明公开
    PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES 有权
    用于生产环状氨基甲酸酯

    公开(公告)号：EP2627642A1

    公开(公告)日：2013-08-21

    申请号：EP11772887.3

    申请日：2011-10-14

    申请人： Lonza Ltd

    发明人： BRENNER, Meinrad ,  CARREIRA, Erick, M. ,  CHINKOV, Nicka ,  LORENZI, Miriam ,  WARM, Aleksander ,  ZIMMERMANN, Lothar

    IPC分类号： C07D265/18

    CPC分类号： C07D265/18

    摘要： The invention is directed to a process for the preparation of a cyclic carbamate starting with o- aminobenzyl alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C 2-5 -alkyl C 2-5 -carboxylates and mixtures of at least one C 2-5 -alkyl C 2-5 -carboxylate with at least one C 5-8 -alkane.