专利检索 ap:("Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center") AND inv:"WALTHER, Frans J." 第 1 页

1.

发明公开
SYNTHETIC LUNG SURFACTANT WITH ENHANCED STABILITY AND EFFECTIVENESS 审中-公开

公开(公告)号：EP3393489A1

公开(公告)日：2018-10-31

申请号：EP16876831.5

申请日：2016-12-16

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： WALTHER, Frans J. , WARING, Alan J. , GORDON, Larry M.

IPC分类号： A61K38/00 , C07K14/435 , C07K19/00 , C12N15/09

CPC分类号： C07K14/785 , A61K38/00

摘要： Peptides suitable for preparation of lung surfactants are described. Examples include one that include a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO: 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO: 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2, wherein X is any amino acid but at least one amino acid at the X positions is not cysteine, or Z is any amino acid but at least one amino acid at the Z positions is not methionine. Surfactants that contain such peptides, and related compositions, methods of preparing and using the compositions are also described.

2.

发明公开
COMPOSITIONS AND METHODS FOR ADMINISTERING PPAR AGONISTS, SURFACTANT PEPTIDES AND PHOSPHOLIPIDS 审中-公开

公开(公告)号：EP3452041A1

公开(公告)日：2019-03-13

申请号：EP17763818.6

申请日：2017-03-06

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： REHAN, Virender K. , TORDAY, John S. , WALTHER, Frans J. , WARING, Alan J. , GORDON, Larry M.

IPC分类号： A61K31/4439 , A61K9/12