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    DICHALCOGENIDE PRODRUGS
    1.
    发明公开
    DICHALCOGENIDE PRODRUGS 审中-公开

    公开(公告)号：EP4071148A1

    公开(公告)日：2022-10-12

    申请号：EP21167187.0

    申请日：2021-04-07

    申请人： Ludwig-Maximilians-Universität München

    发明人： THORN-SESHOLD, Oliver ,  FELBER, Jan ,  ZEISEL, Lukas

    IPC分类号： C07D421/12 ,  C07D421/14 ,  C07D517/04 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

    摘要： The present application relates to a compound having the formula (I)

             A-L-B     (I)

    wherein
    A is represented by

    L is a bond or a self-immolative spacer; and
    B is represented by

    or

    The compound is capable of releasing molecular cargo in the presence of a reductase and is thus suitable for diagnosing or quantifying the activity of the reductase and for treating, ameliorating, preventing or diagnosing a disorder selected from a neoplastic disorder; atherosclerosis; an autoimmune disorder; an inflammatory disease; a chronic inflammatory autoimmune disease; ischaemia; and reperfusion injury.