公开(公告)号：EP1387671A1

公开(公告)日：2004-02-11

申请号：EP02747819.7

申请日：2002-05-02

申请人： MASSACHUSETTS EYE & EAR INFIRMARY ,  THE CHARLES STARK DRAPER LABORATORY, INC.

发明人： ADAMIS, Anthony, P. ,  MILLER, Joan, W. ,  GRAGOUDAS, Evangelos, S. ,  BORENSTEIN, Jeffrey T. ,  MESCHER, Mark, J. ,  WEINSTEIN, Marcie, G. ,  DUBE, Christopher, E. ,  HANSBERRY, Mitchell, L.

IPC分类号： A61K9/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61F2250/0067 ,  A61K9/1647

摘要： The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once attached to the outer surface of an eye, the device can deliver one or more drugs directly into the eye for preventing or ameliorating the symptoms of a particular ocular disorder.

公开(公告)号：EP1154691A1

公开(公告)日：2001-11-21

申请号：EP00908213.2

申请日：2000-01-05

申请人： MASSACHUSETTS EYE & EAR INFIRMARY

发明人： ADAMIS, Anthony, P. ,  GRAGOUDAS, Evangelos, S. ,  MILLER, Joan, W.

IPC分类号： A01N61/00 ,  A01N37/18 ,  A61K31/00 ,  A61K38/00 ,  A61K39/395

CPC分类号： C07K16/24 ,  A61K38/16 ,  A61K2039/505

摘要： The invention provides methods for delivering a therapeutic or diagnostic agent to the eye of a mammal. The method involves contacting sclera with a therapeutic or diagnostic agent so as to permit its passage through the sclera into the choroidal and retinal tissues. The sclera may be contacted with a therapeutic or diagnostic agent together with a device for enhancing transport of the agent through the sclera.