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公开(公告)号：EP1549672A2
公开(公告)日：2005-07-06
申请号：EP03728658.0
申请日：2003-05-02
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C07K2319/01 , C07K2319/30 , C07K2319/43 , C12N2760/18422 , C12N2760/18432 , C12N2760/18443
摘要： The invention provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The invention also provides methods for using viruses to treat cancer patients. Specifically, the invention provides nucleic acid molecules encoding viral hemagglutinin (H) polypeptides, viral H polypeptides, and viruses containing nucleic acids and/or H polypeptides. Such viruses are useful for treating cancer patients without causing immune suppression.
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2.发明公开THERAPEUTIC METHODS AND COMPOSITIONS USING VIRUSES OF THE RECOMBINANT PARAMYXOVIRIDAE FAMILY 有权治疗方法和组合物利用病毒重组副粘病毒科
公开(公告)号：EP1217891A1
公开(公告)日：2002-07-03
申请号：EP00965349.4
申请日：2000-09-22
CPC分类号： C07K14/5434 , A61K2039/505 , C07K14/485 , C07K14/65 , C07K16/2896 , C07K16/3007 , C07K2317/622 , C07K2319/00
摘要： The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent Paramyxoviridae virus comprising two or more of a) a nucleic acid sequence encoding a heterologous polypeptide, wherein upon administration the heterologous polypeptide is detectable in a biological fluid of the patient, and detection of the heterologous polypeptide is indicative of Paramyxoviridae virus growth in the patient and reduction in tumor size; b) a recombinant F protein, H protein, or M protein of Paramyxoviridae virus that increases fusogenicity of virus with cells; c) a nucleic acid sequence encoding a cytokine; and d) a Paramyxoviridae virus that is specific for cells of the tumor.
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