公开(公告)号：EP0341735B1

公开(公告)日：1992-09-30

申请号：EP89108596.1

申请日：1989-05-12

申请人： MECT CORPORATION

发明人： Suda, Isao ,  Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H13/04

公开(公告)号：EP0341735A1

公开(公告)日：1989-11-15

申请号：EP89108596.1

申请日：1989-05-12

申请人： MECT CORPORATION

发明人： Suda, Isao ,  Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H13/04

摘要： An antiviral drug containing N-acetyl-3-fluoroneuraminic acid having the following formula:
or a pharmacologically acceptable salt thereof is disclosed in the present application.

摘要翻译： 在本申请中公开了含有下式的N-乙酰基-3-氟神经氨酸的抗病毒药物：或其药理学上可接受的盐。

公开(公告)号：EP0281067B1

公开(公告)日：1992-04-29

申请号：EP88103065.4

申请日：1988-03-01

申请人： MECT CORPORATION

发明人： Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： C07H13/04 ,  C07H7/027

CPC分类号： C07H13/04

公开(公告)号：EP0281067A3

公开(公告)日：1988-12-14

申请号：EP88103065

申请日：1988-03-01

申请人： MECT CORPORATION

发明人： Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： C07H13/04 ,  C07H07/027

CPC分类号： C07H13/04

摘要： This invention relates to novel derivatives of N-acetyl-­3-fluoro-neurminic acid derivatives (I) and preparation thereof. The compound (I) can be synthesized by reacting a solution of alkyl 5-acetamido-2,6-anhydro-4,7,8,9-tetra-­O-acetyl-2,3,5-trideoxy-D-glycero-D-galacto-2-enonate with (i) an inert gas containing fluorine or (ii) acetylhypo­fluorite obtained by passing the inert gas containing fluorine through a mixture of acetic acid/acetate by passing thereinto, and then removing a solvent and apply­ing the residue through a silica gel column chromatogra­phy.

公开(公告)号：EP0281067A2

公开(公告)日：1988-09-07

申请号：EP88103065.4

申请日：1988-03-01

申请人： MECT CORPORATION

发明人： Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： C07H13/04 ,  C07H7/027

CPC分类号： C07H13/04

摘要： This invention relates to novel derivatives of N-acetyl-­3-fluoro-neurminic acid derivatives (I) and preparation thereof. The compound (I) can be synthesized by reacting a solution of alkyl 5-acetamido-2,6-anhydro-4,7,8,9-tetra-­O-acetyl-2,3,5-trideoxy-D-glycero-D-galacto-2-enonate with (i) an inert gas containing fluorine or (ii) acetylhypo­fluorite obtained by passing the inert gas containing fluorine through a mixture of acetic acid/acetate by passing thereinto, and then removing a solvent and apply­ing the residue through a silica gel column chromatogra­phy.

摘要翻译： 本发明涉及N-乙酰基-3-氟神经氨酸衍生物（I）的新衍生物及其制备方法。 化合物（I）可以通过使5-乙酰氨基-2,6-脱水-4,7,8,9-四-O-乙酰基-2,3,5-三脱氧-D-甘油醚的烷基溶液 （i）含氟的惰性气体或（ii）通过使含有氟的惰性气体通过乙酸/乙酸乙酯的混合物通过而获得的乙酰基次氟酸盐，然后除去溶剂并施加残余物 通过硅胶柱色谱法。