专利检索 ap:("MEDAREX, INC.") AND inv:"ZHU, Lei" 第 1 页

1.

发明公开
MONOCLONAL ANTIBODIES AGAINST PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LACKING IN FUCOSYL RESIDUES 审中-公开
标题翻译：单克隆抗体的前列腺特异膜抗原，在岩藻糖REMAINS MISSING

公开(公告)号：EP1851251A2

公开(公告)日：2007-11-07

申请号：EP06735490.2

申请日：2006-02-17

申请人： MEDAREX, INC.

发明人： CARDARELLI, Josephine, M. , PASSMORE, David, B. , ALBANESE, Jenny , ZHU, Lei

IPC分类号： C07K16/30 , A61P35/00

CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/23 , C07K2317/41 , C07K2317/732 , C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.