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公开(公告)号：EP1590364A2
公开(公告)日：2005-11-02
申请号：EP03799925.7
申请日：2003-12-16
申请人： MEDAREX, INC. , Genmab A/S
发明人： TEELING, Jessica , PARREN, Paul , BAADSGAARD, Ole, D., M., Sc. , HUDSON, Debra , PETERSEN, Jorgen
IPC分类号： C07K1/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1590364B1
公开(公告)日：2011-10-05
申请号：EP03799925.7
申请日：2003-12-16
申请人： Genmab A/S
发明人： TEELING, Jessica , PARREN, Paul , BAADSGAARD, Ole, D., M., Sc. , HUDSON, Debra , PETERSEN, Jorgen
IPC分类号： C07K1/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1558648A2
公开(公告)日：2005-08-03
申请号：EP03809145.0
申请日：2003-10-17
申请人： Genmab A/S
发明人： TEELING, Jessica , RUULS, Sigrid , GLENNIE, Martin , VAN DE WINKEL, Jan, G., J. , PARREN, Paul , PETERSEN, Jorgen , BAADSGAARD, Ole, D., M., Sc. , HUANG, Haichun
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4258 , C07K2317/21 , C07K2317/54 , C07K2317/56 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , G01N33/686
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1558648B1
公开(公告)日：2012-01-11
申请号：EP03809145.0
申请日：2003-10-17
申请人： Genmab A/S
发明人： TEELING, Jessica Woodmill Cottage , RUULS, Sigrid , GLENNIE, Martin , VAN DE WINKEL, Jan, G., J. , PARREN, Paul , PETERSEN, Jorgen , BAADSGAARD, Ole, D., M., Sc. , HUANG, Haichun
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4258 , C07K2317/21 , C07K2317/54 , C07K2317/56 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , G01N33/686
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1597283A2
公开(公告)日：2005-11-23
申请号：EP04714383.9
申请日：2004-02-25
申请人： Genmab A/S
发明人： VAN DE WINKEL, Jan, G., J. , VAN DIJK, Marcus, Antonius , SCHUURMAN, Janine , GERRITSEN, Arnout, F. , BAADSGAARD, Ole, D., M., Sc. , PETERSEN, Jorgen
IPC分类号： C07K16/24 , A61K39/395 , A61P17/06
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1578397A2
公开(公告)日：2005-09-28
申请号：EP03786661.3
申请日：2003-11-14
申请人： Genmab A/S
发明人： SCHUURMAN, Janine , HAVENITH, Catharina, Emanuele, Gerarda , PARREN, Paul , VAN DE WINKEL, Jan, G., J. , WILLIAMS, Denise, Leah , PETERSEN, J rgen , BAADSGAARD, Ole, D., M., Sc.
IPC分类号： A61K9/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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