公开(公告)号：EP2194985A4

公开(公告)日：2012-01-25

申请号：EP08837766

申请日：2008-10-08

申请人： MEDICINES MALARIA VENTURE MMV

发明人： TARNCHOMPOO BONGKOCH ,  YUTHAVONG YONGYUTH ,  VILAIVAN TIRAYUT ,  CHITNUMSUB PENCHIT ,  THONGPANCHANG CHAWANEE ,  KAMCHONWONGPAISAN SUMALEE ,  MATTHEWS DAVID ,  VIVAS LIVIA ,  YUVANIYAMA JIRUNDON ,  CHARMAN SUSAN ,  CHARMAN WILLIAM ,  KATIYAR SANJAY BABU

IPC分类号： C07D239/48 ,  A61K31/495 ,  A61K31/496 ,  C07D401/04 ,  C07D401/12

CPC分类号： C07D401/04 ,  C07D239/48 ,  C07D401/12

摘要： The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.