公开(公告)号：EP1499352A1

公开(公告)日：2005-01-26

申请号：EP03746713.1

申请日：2003-04-11

申请人： MEDIMMUNE, INC. ,  LUDWIG INSTITUTE FOR CANCER RESEARCH

发明人： REED, Jennifer, Lynne ,  DALL'ACQUA, William ,  VAN SNICK, Jacques ,  RENAULD, Jean-Christophe ,  CORMONT, Francoise ,  UYTTENHOVE, Catherine

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/244 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.