公开(公告)号：EP2753706A4

公开(公告)日：2015-08-12

申请号：EP12830128

申请日：2012-08-31

申请人： MEDIMMUNE LLC

发明人： HUNTER ALAN ,  WANG XIANGYANG ,  PABST TIMOTHY ,  WENDELER MICHAELA ,  WANG JIHONG ,  CAREY KENDALL ,  STROUSE ROBERT ,  VARGHESE JOHNSON

IPC分类号： C12P21/02

CPC分类号： C12N9/6429 ,  C07K14/745 ,  C12N9/647

摘要： The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.