专利检索 ap:("MEDPACTO INC") AND inv:"KIM YEUNG CHUL" 第 1 页

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发明公开
MODIFIED DKK2 PROTEIN, NUCLEIC ACID ENCODING THE SAME, PREPARATION METHOD THEREOF, AND USE THEREOF 审中-公开

公开(公告)号：EP3253781A4

公开(公告)日：2018-06-20

申请号：EP16746839

申请日：2016-02-03

申请人： MEDPACTO INC

发明人： HA IL HO , YOO SEOK HO , KIM HYE NAN , KIM YEUNG CHUL , LIM JU RY

IPC分类号： C07K14/47 , A61K38/00 , A61K38/17 , C12N15/63

CPC分类号： C07K14/47 , A61K38/00 , C07K2319/21 , C07K2319/30

摘要： Provided are a modified DKK2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly, a modified DKK2 protein having an additional glycosyl group or improved binding affinity for a substrate LRP6 may be efficiently prepared, thereby being used for promoting angiogenesis or preventing or treating vascular permeability-related diseases.