公开(公告)号：EP1632263A4

公开(公告)日：2008-04-30

申请号：EP04736595

申请日：2004-06-10

申请人： MEDRX CO LTD

发明人： MAENOSONO SHINYA ,  SUZUKI YASUSHI ,  AKITOMO HIROSHI ,  HAMAMOTO HIDETOSHI ,  ISHIBASHI MASAKI

IPC分类号： A61M37/00

CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053

摘要： In the conventional micropatch method, the skin is pricked with solid needles, and vibration is applied by means of a vibrator so as to increase the needle-skin interstice to thereby accomplish drug administration. In the invention, there are provided a pad base for transdermal drug administration whereby transdermal administration of a medicinal drug can be accomplished without need to apply vibration, and provided a process wherein the pad base can easily be produced. One end of each of metal thin wires is immersed in the vertical direction in a synthetic resin raw material solution so as to cause the synthetic resin raw material solution to adhere to the circumference of the metal thin wires. The synthetic resin raw material solution is hardened, and thereafter the metal thin wires are pulled out. Thus, there can be obtained a structure comprising adherent substrate (2) and, disposed erect on the skin side surface thereof, microneedles (1) being tubular and having bell-bottom outer wall. Medicinal drug charged in the hollow portion (3) of microneedles (1) can be injected in the skin, thereby effecting transdermal drug administration. Further, the microneedles (1) are resistant to breaking off because of the bell-bottom shaping.