BAROREFLEX MODULATION WITH CAROTID SINUS NERVE STIMULATION FOR THE TREATMENT OF HEART FAILURE
    1.
    发明公开
    BAROREFLEX MODULATION WITH CAROTID SINUS NERVE STIMULATION FOR THE TREATMENT OF HEART FAILURE 失效
    压力反射调制激波静脉SINE神经刺激心脏衰竭的治疗

    公开(公告)号:EP0862483A1

    公开(公告)日:1998-09-09

    申请号:EP96936854.0

    申请日:1996-10-23

    申请人: MEDTRONIC, INC.

    IPC分类号: A61N1

    摘要: A system and method for stimulating a baroreflex arc based on levels of indicators from the body includes a pacemaker for bradycardia support pacing should the indicators show the need for support pacing. Other indicators and a process take advantage of an assumed relationship between peripheral vascular resistance and pulmonary resistance to determine the level of nerve stimulation required. This level is adjusted or optimized based on its interaction with heart activity and changes in the other indicators. These other indicators are readily available to the implanted device and allow for a process to make an estimate of pulmonary vascular resistance, from which SVR is also estimated. The value determined for SVR is the primary value used to determine the level of nerve stimulation absent indicators for the need to provide bradycardia pacing. The pacemaker can be rate responsive, as can the process for determining the level of nerve stimulation to be delivered. Several different lead configurations are described.

    APPARATUS FOR OPTIMIZING PACEMAKER AV DELAY
    2.
    发明授权
    APPARATUS FOR OPTIMIZING PACEMAKER AV DELAY 失效
    设备以优化AV延迟心脏起搏器

    公开(公告)号:EP0902708B1

    公开(公告)日:2003-09-17

    申请号:EP97920241.3

    申请日:1997-04-09

    申请人: MEDTRONIC, INC.

    IPC分类号: A61N1/368 A61N1/365

    摘要: In a dual chamber cardiac pacemaker, apparatus for determining an atrioventricular (AV) delay interval to maintain optimal left heart AV mechanical synchrony and function. When the intrinsic or paced atrial heart rate is stable, test AV delay intervals are selected and delivered as right ventricular absolute blood pressures (RVP) are measured at the opening of the pulmonary valve. The opening of the pulmonary valve is determined by the peak rate of change in the RVP (dP/dt) following depolarization of the right ventricle. The test AV delay interval providing the lowest amplitude RVP at the peak dP/dt, indicating the lowest pulmonary blood pressure, is selected as the optimal AV delay. The system may be fully contained in an implanted pacemaker system including a right ventricular absolute blood pressure sensor and automatically invoked to determine the optimum AV delay for the prevailing atrial heart rate at any time, or may be invoked at a predetermined time of day or may be invoked by a programmed-in command. The system may also be employed on a temporary basis in conjunction with an implanted dual chamber pacemaker and an external pacemaker programmer with a temporary absolute blood presure sensor to provide the blood pressure signals.

    DUAL CHAMBER PACING SYSTEM AND METHOD WITH CONTINUAL ADJUSTMENT OF THE AV ESCAPE INTERVAL SO AS TO MAINTAIN OPTIMIZED VENTRICULAR PACING FOR TREATING CARDIOMYOPATHY
    4.
    发明公开
    DUAL CHAMBER PACING SYSTEM AND METHOD WITH CONTINUAL ADJUSTMENT OF THE AV ESCAPE INTERVAL SO AS TO MAINTAIN OPTIMIZED VENTRICULAR PACING FOR TREATING CARDIOMYOPATHY 失效
    二腔起搏器和方法连续时间REGELUNGDES AV INTERVALLES具有改进的刺激瞄准的治疗VONKARDIOMYOPATHIEN到达

    公开(公告)号:EP0812223A1

    公开(公告)日:1997-12-17

    申请号:EP96906204.0

    申请日:1996-01-26

    申请人: MEDTRONIC, INC.

    IPC分类号: A61N1

    摘要: A dual chamber pacemaker is provided having capability for adjusting the AV escape interval so as to optimize the timing of delivered ventricular pace pulses for therapy of patients with cardiomyopathy. The pacemaker system continually monitors to determine when a delivered pace pulse results in a fusion beat, and periodically adjusts the AV escape interval in accordance with the percentage or rate of incidence of such fusion beats. In one specific embodiment, the pacing system determines the percentage of delivered ventricular pace pulses which are followed by fusion beats over a predetermined number of intervals, and decrements AV escape interval when such percentage is not below a predetermined minimum. The pacing system also periodically increments AV escape interval when the rate of fusion beats is acceptable, thereby providing a closed loop system for maintaining the AV interval at an optimally long value consistent with maximizing full capture by delivered ventricular pace pulses. In another embodiment, the V-V escape interval of a non-tracking mode pacemaker is controlled to optimize pre-excitation of the ventricle.

    METHOD AND APPARATUS FOR OPTIMIZING PACEMAKER AV DELAY
    6.
    发明公开
    METHOD AND APPARATUS FOR OPTIMIZING PACEMAKER AV DELAY 失效
    方法和设备AV迟迟未能起搏器优化

    公开(公告)号:EP0902708A1

    公开(公告)日:1999-03-24

    申请号:EP97920241.0

    申请日:1997-04-09

    申请人: MEDTRONIC, INC.

    IPC分类号: A61N1

    摘要: In a dual chamber cardiac pacemaker, apparatus for determining an atrioventricular (AV) delay interval to maintain optimal left heart AV mechanical synchrony and function. When the intrinsic or paced atrial heart rate is stable, test AV delay intervals are selected and delivered as right ventricular absolute blood pressures (RVP) are measured at the opening of the pulmonary valve. The opening of the pulmonary valve is determined by the peak rate of change in the RVP (dP/dt) following depolarization of the right ventricle. The test AV delay interval providing the lowest amplitude RVP at the peak dP/dt, indicating the lowest pulmonary blood pressure, is selected as the optimal AV delay. The system may be fully contained in an implanted pacemaker system including a right ventricular absolute blood pressure sensor and automatically invoked to determine the optimum AV delay for the prevailing atrial heart rate at any time, or may be invoked at a predetermined time of day or may be invoked by a programmed-in command. The system may also be employed on a temporary basis in conjunction with an implanted dual chamber pacemaker and an external pacemaker programmer with a temporary absolute blood presure sensor to provide the blood pressure signals.

    APPARATUS FOR DUAL CHAMBER CARDIAC PACING
    7.
    发明授权
    APPARATUS FOR DUAL CHAMBER CARDIAC PACING 失效
    DEVICE两室起搏器

    公开(公告)号:EP0751804B1

    公开(公告)日:1999-06-23

    申请号:EP95909480.6

    申请日:1995-02-06

    申请人: MEDTRONIC, INC.

    IPC分类号: A61N1/365 A61N1/368

    摘要: A dual chamber pacemaker and a method of employing the pacemaker to accomplish atrial synchronized ventricular pacing with complete ventricular capture by control of the A-V escape intervals of the pacer. The maximum A-V escape interval effective to accomplish complete ventricular capture is determined and compared to intrinsic A-V conduction time to derive an offset interval. The offset interval is subtracted from the initially measured conduction time to select initial A-V escape interval durations and is subtracted from A-V conduction times measured after implant of the pacemaker to automatically adjust A-V escape interval durations of the pacemaker to maintain complete ventricular capture.

    METHOD AND APPARATUS FOR DUAL CHAMBER CARDIAC PACING
    8.
    发明公开
    METHOD AND APPARATUS FOR DUAL CHAMBER CARDIAC PACING 失效
    方法和设备的两室起搏器

    公开(公告)号:EP0751804A1

    公开(公告)日:1997-01-08

    申请号:EP95909480.0

    申请日:1995-02-06

    申请人: MEDTRONIC, INC.

    IPC分类号: A61N1

    摘要: A dual chamber pacemaker and a method of employing the pacemaker to accomplish atrial synchronized ventricular pacing with complete ventricular capture by control of the A-V escape intervals of the pacer. The maximum A-V escape interval effective to accomplish complete ventricular capture is determined and compared to intrinsic A-V conduction time to derive an offset interval. The offset interval is subtracted from the initially measured conduction time to select initial A-V escape interval durations and is subtracted from A-V conduction times measured after implant of the pacemaker to automatically adjust A-V escape interval durations of the pacemaker to maintain complete ventricular capture.